DRUGS & SUPPLEMENTS
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Concize is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.
Concize is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Concize is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Concize is excreted by the kidneys, 80% of the administered dose in an unmodified form.
Cryptococcosis, systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.
Dosing regimen of Concize is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Concize should be reduced.
Digestive system: nausea, abdominal pain, diarrhea, flatulence.
CNS: headache, dizziness.
Allergic reactions: skin rash, anaphylactic reactions.
Pregnancy, children up to age 1 year, increased sensitivity to Concize and triazole compounds.
Concize is contraindicated during pregnancy and lactation.
If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.
Concize should be used with caution in patients with severe impaired liver or kidney diseases.
Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.
Simultaneous administration of Concize with:
Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.
Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.
Depending on the reaction of the Concize after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Concize not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Concize addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology