Combined

advertisement
What is the dose of the medication you are taking?

Combined uses

Combined consists of Fluoxetine Hydrochloride, Olanzapine.

Fluoxetine Hydrochloride:


Pharmacological action

Combined is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Combined (Fluoxetine Hydrochloride) is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Combined (Fluoxetine Hydrochloride) apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Combined (Fluoxetine Hydrochloride) does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.

Pharmacokinetics

Combined (Fluoxetine Hydrochloride) absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Combined (Fluoxetine Hydrochloride) easily penetrates through the BBB.

Combined (Fluoxetine Hydrochloride) metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

T1/2 of Combined (Fluoxetine Hydrochloride) is 2-3 days, norfluoxetine - 7-9 days.

Why is Combined prescribed?

Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage and administration

The initial dose of Combined is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

The maximum oral daily dose for adults is 80 mg.

Combined (Fluoxetine Hydrochloride) side effects, adverse reactions

CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

Digestive system: diarrhea, nausea.

Metabolism: increased sweating, hypoglycemia, hyponatremia (especially in elderly patients and when hypovolemia).

Reproductive system: decreased libido.

Allergic reactions: skin rash, itching.

Other: pain in joints and muscles, shortness of breath, increased body temperature.

advertisement

Combined contraindications

Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Combined (Fluoxetine Hydrochloride).

Using during pregnancy and breastfeeding

Combined is contraindicated during pregnancy and lactation.

Special instructions

Combined (Fluoxetine Hydrochloride) should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Combined (Fluoxetine Hydrochloride) increases the risk of epileptic seizures.

With the simultaneous application of Combined (Fluoxetine Hydrochloride) and electroconvulsive therapy may develop prolonged seizures.

Combined (Fluoxetine Hydrochloride) can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Combined (Fluoxetine Hydrochloride) before therapy MAO inhibitors should not be less than 5 weeks.

Elderly patients need correction of dosing regimen.

Safety of Combined (Fluoxetine Hydrochloride) in children has not been established.

During the period of treatment it needed to avoid use alcohol.

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Combined drug interactions

Simultaneous administration of Combined (Fluoxetine Hydrochloride) with:

  • drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
  • MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome (confusion, hypomanic state, motor restlessness, agitation, convulsions, dysarthria, hypertensive crisis, fever, tremor, nausea, vomiting, diarrhea);
  • Combined (Fluoxetine Hydrochloride) inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
  • it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
  • hypoglycemic agents may increase their activities;
  • haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
  • with lithium salts may increase or decrease the concentration of lithium in blood plasma;
  • may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of Combined (Fluoxetine Hydrochloride) Sanis Health);
  • propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
  • may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with Combined (Fluoxetine Hydrochloride).

    Combined in case of emergency / overdose

    Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Combined (Fluoxetine Hydrochloride) (in combination with maprotiline, codeine, temazepam).

    Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.

  • Olanzapine:


    Combined information

    This medication is a well-known drug used for the corrective treatment of neuro-psychiatric disorders like schizophrenia. Combined (Olanzapine) is also used for correcting mental disorders like acute mania or bipolar disorder, to be specific. This drug can also be coupled up with both divalproex and lithium, for combination therapy. Combined (Olanzapine) is a nascent member of the anti-psychotic group of drugs that affects the human psyche. Already an established choice of physicians and sufferers, Combined (Olanzapine) balances the chemicals naturally found in human brain to stabilize the agonizing symptoms of a schizophrenic. The popularity of this drug has increased in the recent times due to its better and faster actions in controlling and lessening symptoms like delusions, apathy, hallucinations, social alienation over traditional anti-psychotics drugs. Combined (Olanzapine), is however, effective in treating other disorders as well.

    Combined warnings

    It is always advisable to consult your physician before taking the drug. Special care needs to be taken if you have problems pertaining to the liver or heart. Also ask your doctor whether it will be judicious or not to take this drug if you have chronic diseases like epilepsy, diabetes, enlarged prostrate, glaucoma or phenylketonuria syndromes. Listed in category C of FDA pregnancy, it is difficult to say for sure whether this drug is safe during pregnancy or not. So it is always better to consult a physician if anyone wants to use this drug during pre natal or breast-feeding stage.

    Because of its nerve soothing factors, Combined (Olanzapine) sometimes may cause dizziness and hamper judgment, thinking, and motor skills. It can also interfere with body temperature regulation. So it is better to be very careful while driving. New users of Combined (Olanzapine) may experience a condition called Neuroleptic Malignant Syndrome. The normally found symptoms of this condition are high fever, muscle rigidity, irregular pulse or blood pressure, rapid heartbeat, excessive perspiration, and changes in heart rhythm. Don't delay to see a doctor if any of these symptoms appear. Use of Combined (Olanzapine) in case of elderly women involves a risk of developing Tardive dyskinesia. This condition involves slow, rhythmical, involuntary movements. This problem, though more found in women, also surfaces in older adults. The use of this drug should be immediately stopped if any such symptom appears. Combined (Olanzapine) is also not advisable for children having phenylketonuria syndrome.

    Combined (Olanzapine) may not work in harmony if you are already using any of the following drugs:

    Carbamazepine (Tegretol)

    Fluvoxamine (Luvox)

    Levodopa (Sinemet, Larodopa, Atamet, Stalevo)

    Selegiline (Eldepryl)

    Pramipexole (Mirapex)

    Ropinirole (Requip)

    advertisement

    Combined side effects

    The most prominent side effects of the drug Combined (Olanzapine) include dizziness, drowsiness, dry mouth, fatigue, constipation, upset stomach, increased appetite, or mild trembling, weight gain etc. Consulting a physician is the best way out in such cases as there are tested alternatives to correct such side effects.

    Combined (Olanzapine) can also give birth to serious side effects like severe abdominal pain, abnormal gait, irritation, anxiety, back pain, behavior problems, blood in urine, blurred vision, chest pain, cough, dehydration, fluctuating blood pressure, eye problems, feeling of well-being, fever, headache, hostility, indigestion, inflammation of the nasal passages and throat, insomnia, joint pain, movement disorders, muscle rigidity, nausea, nervousness, pain in arms and legs, rapid heartbeat, restlessness, abnormal dreams. Cases with decreased sex drive, dental pain, breathing trouble, emotional instability, involuntary movement, joint stiffness, menstrual irregularities, sleepiness, suicide attempts, sweating, swelling of arms and legs, thirst, twitching, urinary problems, vaginal infection, vomiting after usage of Combined (Olanzapine) are also abundant.

    Cases with side effects like black bowel movements, stomach upset, abnormal ejaculation, bleeding, blood clots, breast pain, bone pain, breast growth in males, burping, chills, congestive heart failure, difficulty swallowing, dry eyes, dry skin, ear pain, change in taste sensation, enlarged abdomen, fever, hair loss, hangover feeling, heart attack, inability to control bowel movements, migraine, mouth sores, neck pain, neck rigidity, osteoporosis, pallor, rash, rectal bleeding, rheumatoid arthritis, ringing in the ears, sensitivity to light, stroke, sudden death, swelling of face, swollen gums, yeast infection are rare but cannot be ruled out. It is advisable to see a doctor if any such symptom appears.

    Combined overdose

    There is no denying the fact that Combined (Olanzapine) is a wonder drug. But to be on the safer side it is always better to consult a physician and be sure about what is the right dose for you. So far no serious cases of Combined (Olanzapine) overdose has been found. Overdose of the drug may not be detrimental to your existence but it can always cause fatal disorders. The symptoms of overdose generally include drowsiness and haltered speech. As soon as you feel that an overdose has been taken by mistake rush to a doctor for the corrective measures.

    On the other hand, a missed dose of Combined (Olanzapine) does not cause harmful damages. But as soon as you notice that a dose is missed take the missed dose. But if it is almost time for the next regularly scheduled dose, just skip the earlier dose and take the scheduled one. Remember, a wonder drug can cause fatal effects if taken without care.

    Combined usage guidelines

    Always follow the doctor's prescription for the right usage guideline. Normally Combined (Olanzapine) tablets should be taken in with a full glass of water. Usually taken once a day, Combined (Olanzapine) can be taken with or without food. Combined (Olanzapine) is also available in an injectable form. For the right dose always consult your physician. Don't stop using this drug without consulting your physician.

    If the doctor suggests certain regular diagnostic check up or blood tests for evaluating the progress and side effects of the drug, don't ignore doing that. Also to get the best results don't forget to store Combined (Olanzapine) at room temperature and keep away from moisture and heat.

    advertisement

    Combined pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Combined available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Combined destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Combined Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Combined pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


    advertisement

    References

    1. Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. Dailymed."ZYPREXA (OLANZAPINE) TABLET [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    3. Dailymed."FLUOXETINE HYDROCHLORIDE; OLANZAPINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Combined?

    Depending on the reaction of the Combined after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Combined not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Combined addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

    advertisement

    Review

    sdrugs.com conducted a study on Combined, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Combined consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    Visitor reported useful

    No survey data has been collected yet

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    Visitor reported frequency of use

    No survey data has been collected yet

    Visitor reported doses

    No survey data has been collected yet

    Visitor reported time for results

    No survey data has been collected yet

    Visitor reported administration

    No survey data has been collected yet

    Visitor reported age

    No survey data has been collected yet

    Visitor reviews


    There are no reviews yet. Be the first to write one!


    Your name: 
    Email: 
    Spam protection:  < Type 21 here

    The information was verified by Dr. Arunabha Ray, MD Pharmacology

    © 2002 - 2021 "sdrugs.com". All Rights Reserved