Colmifen

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What are the side effects you encounter while taking this medicine?

Colmifen uses


Pharmacological action

Colmifen is a centrally acting muscle relaxant; GABAB-receptor agonist. It depresses mono-and polysynaptic reflexes presumably by reducing the release of excitatory amino acids from the terminals which occurs as a result of stimulation of presynaptic GABA-receptors. This medication does not affect the transmission of impulses in the nerve-muscle synapses; reduces skeletal muscle tone; has a moderate analgesic effect.

Pharmacokinetics

When Colmifen administered orally Colmifen is rapidly and completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved in 2-3 hours after administration. Plasma protein binding is about 30%. Colmifen crosses the placental barrier, excreted in breast milk; metabolized in the liver; excreted in the urine, mainly unchanged.

Why is Colmifen prescribed?

skeletal muscle spasticity in multiple sclerosis

spastic conditions of the spinal cord in diseases of infectious, degenerative, traumatic genesis

children cerebral palsy

Dosage and administration

For oral administration of Colmifen for adults at the beginning of treatment - 5 mg 3 times / day. For each 4-day treatment dose increased to 5 mg 3 times / day to the development of optimal therapeutic effect. Average daily dose is 30-75 mg, if necessary may increase up to 100-120 mg. The final daily dose is set individually so that together with the weakening of clonus and muscle spasms persisted muscle tone, which is sufficient for the implementation of active movements.

For patients with increased sensitivity to pharmaceutical drugs initial daily dose of Colmifen may be 5-10 mg, followed by a slower increase. For patients with renal insufficiency and during hemodialysis daily dose is 5 mg.

For children under 10 years daily dose is 0.75-2 mg / kg, over 10 years - 2.5 mg / kg. Treatment starts with a dose of 2.5 mg 4 times / day. Daily dose as for adults choose individually, increasing it every 3 days, in accordance with the clinical course of disease. Maintenance dose for children aged 1-2 years is 10-20 mg / day; for children aged 2-10 years - 30-60 mg / day.

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Colmifen side effects, adverse reactions

CNS and peripheral nervous system: drowsiness, dizziness ; sometimes - apathy, fatigue, sleep disturbances, confusion; rarely - euphoria, depression, paresthesia, myalgia, muscle weakness, ataxia, tremor, nystagmus, accommodation disturbances, hallucinations; may be more frequent seizures and lowering the threshold of their appearance.

Digestive system: nausea, sometimes there are dry mouth, constipation, diarrhea, and in some cases - liver function abnormalities.

Cardiovascular system: sometimes - hypotension, deterioration of the cardiovascular system.

Other: sometimes - respiratory depression, rarely - dysuria, enuresis.

Side effects occur mainly at the beginning of treatment, with the rapid increase in dose, when administered a dose of 60 mg / day, as well as in elderly patients.

Contraindications

During pregnancy (especially in I trimester) Colmifen can be used only for health reasons.

Special instructions

Selection of individual daily dose of Colmifen recommended in the hospital.

Side effects are often transient, may disappear or decrease at lower doses of Colmifen Sanis Health. The need to interrupt therapy is rare. Side effects of Colmifen should be distinguished from symptoms of the disease which are treated. A cancellation of Colmifen should be conducted gradually, reducing the dose for 1-2 weeks.

With careful use in cerebrovascular disorders, psychotic states, schizophrenia, stomach ulcers and duodenal ulcers, respiratory failure, violations of liver and kidney, as well as in elderly patients. If concomitant treatment of epilepsy should be under strict medical supervision and without interruption of adequate therapy by anticonvulsant drugs. Patients with dysuria after Colmifen treatment can be observed hypertonicity of sphincter of the bladder and urine retention.

In patients with liver disease and diabetes should periodically monitor the level of hepatic transaminases, alkaline phosphatase and blood sugar.

During the treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Colmifen drug interactions

With the simultaneous application of Colmifen increases the effects of antihypertensive drugs, ethanol.

In an application of Colmifen with tricyclic antidepressants can significantly decrease muscle tone.

There is a described case of toxic reactions caused by the action of Colmifen (disturbance of consciousness, confusion, bradycardia, impaired visual acuity, hypotension, hypothermia) while using with ibuprofen in elderly patients with impaired renal function.

In an application with lithium therapy may be severe manifestations of hyperkinetic symptoms.

Patients suffering from Parkinson's disease while the application of Colmifen with levodopa and carbidopa may have hallucinations, confusion, agitation.

Colmifen in case of emergency / overdose

Symptoms: vomiting, muscular hypotonia, drowsiness, impaired accommodation of the eye, coma, respiratory depression, convulsions.

Treatment: induction of vomiting or gastric lavage, taking activated charcoal, symptomatic and supportive therapy (mechanical ventilation, maintenance of cardiovascular activity). There is no specific antidote.

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Colmifen pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Colmifen available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Colmifen destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Colmifen Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Colmifen pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."BACLOFEN TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."BACLOFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "baclofen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Colmifen?

Depending on the reaction of the Colmifen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Colmifen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Colmifen addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Colmifen, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Colmifen consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Colmifen useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Not useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

Four visitors reported frequency of use

How often in a day do you take the medicine?
Are you taking the Colmifen drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Colmifen is mentioned below.
Visitors%
Once in a day2
50.0%
3 times in a day2
50.0%

Six visitors reported doses

What is the dose of Colmifen drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 6-10mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
6-10mg6
100.0%

Two visitors reported time for results

What is the time duration Colmifen drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 week to notice the result from using Colmifen drug. The time needed to show improvement in health condition after using the medicine Colmifen need not be same for all the users. It varies based on other factors.
Visitors%
1 week1
50.0%
2 days1
50.0%

Visitor reported administration

No survey data has been collected yet

Four visitors reported age

Visitors%
30-452
50.0%
> 601
25.0%
46-601
25.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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