DRUGS & SUPPLEMENTS
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Co-Fluampicil Injection is an antibiotic of semisynthetic broad-spectrum penicillin group. This medication has a bactericidal effect by suppressing the synthesis of bacterial cell walls. Co-Fluampicil Injection (Ampicillin Sodium) is active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Enterococcus spp., Listeria monocytogenes; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Co-Fluampicil Injection (Ampicillin Sodium) destroyed by penicillinase. This drug is acid-resistant.
After oral administration Co-Fluampicil Injection (Ampicillin Sodium) is well absorbed from the gastrointestinal tract. This medicine is distributed in most organs and tissues; crosses the placental barrier, poorly penetrates the BBB. When inflammation of the meninges, BBB permeability increases dramatically. 30% of Co-Fluampicil Injection (Ampicillin Sodium) is metabolized in the liver. This medication is excreted in the urine and bile.
Infectious-inflammatory diseases caused by organisms susceptible to Co-Fluampicil Injection (Ampicillin Sodium): including ear infections, throat, nose, odontogenic infections, bronchopulmonary infections, acute and chronic urinary tract infections, gastrointestinal infections (including salmonella, cholecystitis), gynecological infections, meningitis, endocarditis, septicemia, sepsis, rheumatic fever, erysipelas, scarlet fever, infections of skin and soft tissues.
The dosing regimen of Co-Fluampicil Injection is set individually depending on the severity, localization of infection and sensitivity of the pathogen.
For adults for oral administration a single dose of this medication is 250-500 mg, the multiplicity of the reception is 4 times / day. The dose for children weighing up to 20 kg is 12.5-25 mg / kg every 6 hours.
For IV and IM using the single dose for adults is 250-500 mg every 4-6 hours; for children the single dose is 25-50 mg / kg.
The duration of treatment depends on the localization of infection and features of the disease.
The maximum oral daily dose for adults is 4 g, for IM and IV administration - 14 g.
Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, extremely rare - anaphylactic shock.
Digestive system: nausea, vomiting.
The effects caused by chemotherapeutic action: oral candidiasis, vaginal candidiasis, intestinal dysbiosis, colitis caused by Clostridium difficile.
Infectious mononucleosis, lymphatic leukemia, increased sensitivity to Co-Fluampicil Injection (Ampicillin Sodium) and other penicillins, abnormal liver function.
Perhaps the use of Co-Fluampicil Injection during pregnancy if it may be needed. Co-Fluampicil Injection (Ampicillin Sodium) is excreted in breast milk in low concentrations. If necessary to use Co-Fluampicil Injection (Ampicillin Sodium) in the lactation period it should be solved the issue of termination of breastfeeding.
Category effects on the fetus by FDA - B.
In the course of treatment with Co-Fluampicil Injection (Ampicillin Sodium) there is need the regular control of renal function, liver and peripheral blood picture. Patients with impaired renal function requires correction dosing regimen in accordance with the values of CCr.
When used in high doses in patients with renal insufficiency it may be toxic effects on the CNS.
For using of Co-Fluampicil Injection (Ampicillin Sodium) in patients with bacteremia (sepsis) it can be bacteriolysis reaction (Jarisch-Herxheimer reaction).
Simultaneous administration of Co-Fluampicil Injection (Ampicillin Sodium) with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) there is manifested synergism; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.
Co-Fluampicil Injection (Ampicillin Sodium) enhances the effect of indirect anticoagulants by inhibiting the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
Co-Fluampicil Injection (Ampicillin Sodium) decreases the effect of drugs in the process of metabolism which produce PABA.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Co-Fluampicil Injection (Ampicillin Sodium) which may be accompanied by an increase in its concentration in blood plasma.
Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of Co-Fluampicil Injection (Ampicillin Sodium) Upha Corporation. Ascorbic acid increases the absorption of Co-Fluampicil Injection (Ampicillin Sodium).
Co-Fluampicil Injection (Ampicillin Sodium) decreases the effectiveness of oral contraceptives.
Symptoms: the toxic effect on the central nervous system (especially in patients with renal insufficiency), nausea, vomiting, diarrhea, impaired water and electrolyte balance (as a consequence of vomiting and diarrhea).
Treatment: gastric lavage, activated charcoal, saline laxatives, a maintain of water and electrolyte balance, symptomatic therapy. This drug is derived by means of hemodialysis.
Indication: Used to treat bacterial infection by susceptible microorganisms.
Co-Fluampicil Injection (Flucloxacillin Sodium) is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Co-Fluampicil Injection (Flucloxacillin Sodium) has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Co-Fluampicil Injection (Flucloxacillin Sodium) results from the inhibition of cell wall synthesis and is mediated through Co-Fluampicil Injection (Flucloxacillin Sodium) binding to penicillin binding proteins (PBPs). Co-Fluampicil Injection (Flucloxacillin Sodium) is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Depending on the reaction of the Co-Fluampicil Injection after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Co-Fluampicil Injection not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Co-Fluampicil Injection addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology