Clexane is a low molecular weight heparin. Clexane is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Clexane binds to and accelerates the activity of antithrombin III. By activating antithrombin III, Clexane preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Indication: For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Clexane is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from 3800 to 5000 daltons. Clexane occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Clexane is a well known and commonly used anticoagulant which has antithrombotic properties. Clexane inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Clexane acts at multiple sites in the normal coagulation system. Small amounts of Clexane in combination with antithrombin III (enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of Clexane can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Clexane also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Its use should be avoided in patients with a creatinine clearance less than 20mL/min. In these patients, unfractionated heparin should only be used. As for monitoring, active partial thromboplastin time (aPTT) will only increase at high doses of low molecular weight heparins (LMWH). Therefore, monitoring aPTT is not recommended. However, anti-Xa activity can be measured to monitor the efficacy of the LMWH.
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Clexane pharmaceutical active ingredients containing related brand and generic drugs:
Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.
Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results. Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable. Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.
Injectable; Injection; Enoxaparin Sodium 10,000 IU
Injectable; Injection; Enoxaparin Sodium 12,000 IU
Injectable; Injection; Enoxaparin Sodium 15,000 IU
Injectable; Injection; Enoxaparin Sodium 2000 IU
Injectable; Injection; Enoxaparin Sodium 4000 IU
Injectable; Injection; Enoxaparin Sodium 6000 IU
Injectable; Injection; Enoxaparin Sodium 8000 IU
Injectable; Injection; Enoxaparin Sodium 9000 IU
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Clexane destination | category:
Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination. Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.
Human:
Anticoagulants, antiplatelets and fibrinolytics (thrombolytics)
Heparins
Clexane Anatomical Therapeutic Chemical codes:
A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.
Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug. Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.
Can i drive or operate heavy machine after consuming Clexane?
Depending on the reaction of the Clexane after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Clexane not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Clexane addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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Review
sdrugs.com conducted a study on Clexane, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Clexane consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.
Visitor reports
Visitor reported useful
No survey data has been collected yet
Three visitors reported side effects
Did you get side effects while taking the Clexane drug, or were there no side effects? According to the survey conducted by website sdrugs.com users, the below-mentioned percentages indicate the number of people experiencing the side effects and the number of people not experiencing the side effects when taking Clexane medicine. Every drug produces minimal side effects, and they are negligible most times, when compared to the desired effect [use] of the medicine. Side effects depend on the dose you are taking, any drug interactions that happen when you are on other medications, if the patient is sensitive, and other associated conditions. If you cannot tolerate the side effects, consult your doctor immediately, so he can either adjust the dose or change the medication.
Visitors
%
No side effects
3
100.0%
Visitor reported price estimates
No survey data has been collected yet
Nine visitors reported frequency of use
How often in a day do you take the medicine? Are you taking the Clexane drug as prescribed by the doctor? Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Clexane is mentioned below.
Visitors
%
Twice in a day
5
55.6%
Once in a day
3
33.3%
3 times in a day
1
11.1%
Seven visitors reported doses
What is the dose of Clexane drug you are taking? According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors
%
11-50mg
5
71.4%
101-200mg
1
14.3%
6-10mg
1
14.3%
Two visitors reported time for results
What is the time duration Clexane drug must be taken for it to be effective or for it to reduce the symptoms? Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Clexane drug. The time needed to show improvement in health condition after using the medicine Clexane need not be same for all the users. It varies based on other factors.
Visitors
%
1 day
1
50.0%
2 weeks
1
50.0%
Two visitors reported administration
The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Clexane drug, before food or after food? Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors
%
After food
2
100.0%
Six visitors reported age
Visitors
%
46-60
2
33.3%
30-45
2
33.3%
16-29
1
16.7%
> 60
1
16.7%
Visitor reviews
There are no reviews yet. Be the first to write one!
