DRUGS & SUPPLEMENTS

Ciprofloxacin

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Ciprofloxacin uses


DESCRIPTION SECTION

Ciprofloxacin Ophthalmic Solution is a synthetic, sterile, multiple dose, antimicrobial for topical use. Ciprofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of gram positive and gram-negative ocular pathogens. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7--3-quinoline-carboxylic acid. It is a faint to light yellow crystalline powder with a molecular weight of 385.8. Its empirical formula is C17H18FN3O3-HCl-H2O and its chemical structure is as follows:


Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position.

Each mL of Ciprofloxacin Ophthalmic Solution contains: Active: Ciprofloxacin HCl 3.5 mg equivalent to 3 mg base. Preservative: benzalkonium chloride 0.006%. Inactives: sodium acetate, acetic acid, mannitol 4.6%, edetate disodium 0.05%, hydrochloric acid and/or sodium hydroxide (to adjust pH) and Water for Injection. The pH is approximately 4.5 and the osmolality is approximately 300 mOsm.

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CLINICAL PHARMACOLOGY SECTION

Systemic Absorption: A systemic absorption study was performed in which Ciprofloxacin Ophthalmic Solution was administered in each eye every two hours while awake for two days followed by every four hours while awake for an additional 5 days. The maximum reported plasma concentration of Ciprofloxacin was less than 5 ng/mL. The mean concentration was usually less than 2.5 ng/mL.

Microbiology: Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of Ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA. Ciprofloxacin has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections (SEE INDICATIONS AND USAGE section):

Gram-Positive:

Staphylococcus aureus

Staphylococcus epidermidis

Streptococcus pneumoniae

Streptococcus (Viridans Group)

Gram-Negative:

Haemophilus influenzae

Pseudomonas aeruginosa

Serratia marcescens

Ciprofloxacin has been shown to be active in vitro against most strains of the following organisms, however, the clinical significance of these data is unknown:

Gram-Positive:

Enterococcus faecalis (Many strains are only moderately susceptible)

Staphylococcus haemolyticus

Staphylococcus hominis

Staphylococcus saprophyticus

Streptococcus pyogenes

Gram-Negative

Acinetobacter calcoaceticus Escherichia coli Proteus mirabilis

subsp. anitratus Haemophilus ducreyi Proteus vulgaris 

Aeromonas caviae Haemophilus parainfluenzae Providencia rettgeri

Aeromonas hydrophila Kiebsiella pneumoniae Providencia stuartii

Brucella melitensis Kiebsiella oxytoca Salmonella enteritidis

Campylobacter coli Legionella pneumophila Salmonella typhi

Campylobacter jejuni Moraxella (Branhamella) Shigella sonneii

Citrobacter diversus catarrhalis Shigella flexneri

Citrobacter freundii Morganella morganii Vibrio cholerae

Edwardsiella tarda Neisseria gonorrhoeae Vibrio parahaemolyticus

Enterobacter aerogenes Neisseria meningitidis Vibrio vulnificus

Enterobacter cloacae Pasteurella multocida Yersinia enterocolitica

Other Organisms: Chlamydia trachomatis (only moderately susceptible) and Mycobacterium tuberculosis (only moderately susceptible).

Most strains of Pseudomonas cepacia and some strains of Pseudomonas maltophilia are resistant to Ciprofloxacin as are most anaerobic bacteria, including Bacteroides fragilis and Clostridium difficile. The minimal bactericidal concentration (MBC) generally does not exceed the minimal inhibitory concentration (MIC) by more than a factor of 2. Resistance to Ciprofloxacin in vitro usually develops slowly (multiple-step mutation).

Ciprofloxacin does not cross-react with other antimicrobial agents such as beta-lactams or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to Ciprofloxacin.

Clinical Studies: Following therapy with Ciprofloxacin Ophthalmic Solution, 76% of the patients with corneal ulcers and positive bacterial cultures were clinically cured and complete re-epithelialization occurred in about 92% of the ulcers. In 3 and 7 day multicenter clinical trials, 52% of the patients with conjunctivitis and positive conjunctival cultures were clinically cured and 70-80% had all causative pathogens eradicated by the end of treatment.

INDICATIONS & USAGE SECTION

Ciprofloxacin Ophthalmic Solution is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:

Corneal Ulcers: Pseudomonas aeruginosa

Serratia marcescens * 

Staphylococcus aureus

Staphylococcus epidermidis

Streptococcus pneumoniae

Streptococcus  * 

Conjunctivitis: Haemophilus influenzae

Staphylococcus aureus

Staphylococcus epidermidis

Streptococcus pneumoniae

* Efficacy for this organism was studied in fewer than 10 infections.

CONTRAINDICATIONS SECTION

A history of hypersensitivity to Ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of Ciprofloxacin.

WARNINGS SECTION

NOT FOR INJECTION INTO THE EYE.

Serious and occasionally fatal hypersensitivity reactions, some following the first dose, have been reported in patients receiving systemic quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine and other resuscitation measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated. Remove contact lenses before using.

PRECAUTIONS SECTION

General: As with other antibacterial preparations, prolonged use of Ciprofloxacin may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Ciprofloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction. In clinical studies of patients with bacterial corneal ulcer, a white crystalline precipitate located in the superficial portion of the corneal defect was observed in 35 (16.6%) of 210 patients. The onset of the precipitate was within 24 hours to 7 days after starting therapy. In one patient, the precipitate was immediately irrigated out upon its appearance. In 17 patients, resolution of the precipitate was seen in 1 to 8 days (seven within the first 24-72 hours), in five patients, resolution was noted in 10-13 days. In nine patients, exact resolution days were unavailable; however, at follow-up examinations, 18-44 days after onset of the event, complete resolution of the precipitate was noted. In three patients, outcome information was unavailable. The precipitate did not preclude continued use of Ciprofloxacin, nor did it adversely affect the clinical course of the ulcer or visual outcome. (SEE ADVERSE REACTIONS).

Information for patients: Do not touch dropper tip to any surface, as this may contaminate the solution.

Drug Interactions: Specific drug interaction studies have not been conducted with ophthalmic Ciprofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Carcinogenesis, Mutagenesis, Impairment of Fertility: 

Eight in vitro mutagenicity tests have been conducted with Ciprofloxacin and the test results are listed below:

Salmonella/Microsome Test (Negative)

E. coli DNA Repair Assay (Negative)

Mouse Lymphoma Cell Forward Mutation Assay (Positive)

Chinese Hamster V79 Cell HGPRT Test (Negative)

Syrian Hamster Embryo Cell Transformation Assay (Negative)

Saccharomyces cerevisiae Point Mutation Assay (Negative)

Saccharomyces cerevisiae Mitotic Crossover and Gene Conversion Assay (Negative)

Rat Hepatocyte DNA Repair Assay (Positive)

Thus, two of the eight tests were positive, but the results of the following three in vivo test systems gave negative results:

Rat Hepatocyte DNA Repair Assay

Micronucleus Test (Mice)

Dominant Lethal Test (Mice).

Long term carcinogenicity studies in mice and rats have been completed. After daily oral dosing for up to two years, there is no evidence that Ciprofloxacin had any carcinogenic or tumorigenic effects in these species.

Pregnancy: Pregnancy Category C. Reproduction studies have been performed in rats and mice at doses up to six times the usual daily human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to Ciprofloxacin. In rabbits, as with most antimicrobial agents, Ciprofloxacin (30 and 100 mg/kg orally) produced gastrointestinal disturbances resulting in maternal weight loss and an increased incidence of abortion. No teratogenicity was observed at either dose. After intravenous administration, at doses up to 20 mg/kg, no maternal toxicity was produced and no embryotoxicity or teratogenicity was observed. There are no adequate and well controlled studies in pregnant women. Ciprofloxacin Ophthalmic Solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers: It is not known whether topically applied Ciprofloxacin is excreted in human milk. However, it is known that orally administered Ciprofloxacin is excreted in the milk of lactating rats and oral Ciprofloxacin has been reported in human breast milk after a single 500 mg dose. Caution should be exercised when Ciprofloxacin Ophthalmic Solution is administered to a nursing mother.

Pediatric Use: Safety and effectiveness in pediatric patients below the age of 1 year have not been established. Although Ciprofloxacin and other quinolones cause arthropathy in immature animals after oral administration, topical ocular administration of Ciprofloxacin to immature animals did not cause any arthropathy and there is no evidence that the ophthalmic dosage form has any effect on the weight bearing joints.

Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

ADVERSE REACTIONS SECTION

The most frequently reported drug related adverse reaction was local burning or discomfort. In corneal ulcer studies with frequent administration of the drug, white crystalline precipitates were seen in approximately 17% of patients. Other reactions occurring in less than 10% of patients included lid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia and a bad taste following instillation. Additional events occurring in less than 1% of patients included corneal staining, keratopathy/keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, nausea and decreased vision.

to report suspected adverse reactions call 1-800-332-1088 to report suspected adverse reactions call 1-800-332-1088

OVERDOSAGE SECTION

A topical overdose of Ciprofloxacin Ophthalmic Solution may be flushed from the eye(s) with warm tap water.

DOSAGE & ADMINISTRATION SECTION

Corneal Ulcers: The recommended dosage regimen for the treatment of corneal ulcers is two drops into the affected eye every 15 minutes for the first six hours and then two drops into the affected eye every 30 minutes for the remainder of the first day. On the second day, instill two drops in the affected eye hourly. On the third through the fourteenth day, place two drops in the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.

Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is one or two drops instilled into the conjunctival sac every two hours while awake for two days and one or two drops every four hours while awake for the next five days.

How Supplied: As a sterile ophthalmic solution, in a plastic dispenser:

2.5 mL  NDC16571-120-25

5 mL     NDC16571-120-50

STORAGE: Store at 25°C (77°F); excursions permitted to15 - 30°C (59 - 86°F). Protect from light. Retain in carton until contents are used.

ANIMAL PHARMACOLOGY & OR TOXICOLOGY SECTION

Ciprofloxacin and related drugs have been shown to cause arthropathy in immature animals of most species tested following oral administration. However, a one-month topical ocular study using immature Beagle dogs did not demonstrate any articular lesions.

Rx Only

Manufactured in India for:

Nexus Pharmaceuticals Inc.,

Distributed by: Pack Pharmaceuticals, LLC, Buffalo Grove, IL, 60089.

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PACKAGE LABEL.PRINCIPAL DISPLAY PANEL


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Ciprofloxacin pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Ciprofloxacin available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Apo-Ciproflox 0.3 % Solution1.18 USD
Cetraxal 0.2% ear solution7.14 USD
Ciloxan 0.3 % Solution2.18 USD
Ciloxan 0.3% Ointment 3.5 gm Tube87.49 USD
Ciloxan 0.3% Solution 5ml Bottle68.33 USD
Ciloxan 0.3% eye drops13.33 USD
Cipro 250 mg tablet5.2 USD
Cipro 250 mg/5ml(5%) Suspension 100ml Bottle116.8 USD
Cipro 400 mg Solution 40ml Vial259.99 USD
Cipro 500 mg tablet6.08 USD
Cipro 500 mg/5ml(10%) Suspension 100ml Bottle136.75 USD
Cipro 750 mg tablet6.26 USD
Cipro HC 0.2-1% Suspension 10ml Bottle131.54 USD
Cipro XR 1000 mg 24 Hour tablet10.75 USD
Cipro XR 500 mg 24 Hour tablet10.88 USD
Cipro hc otic suspension12.65 USD
Cipro i.v. 10 mg/ml vial0.72 USD
Cipro i.v. 200 mg/100 ml d5w0.16 USD
Cipro xr 1000 mg tablet11.91 USD
Cipro xr 500 mg tablet10.46 USD
Ciprofloxacin 0.3% eye drop12.96 USD
Ciprofloxacin 200 mg/20 ml vial0.13 USD
Ciprofloxacin HCl 0.3% Solution 10ml Bottle98.22 USD
Ciprofloxacin HCl 0.3% Solution 2.5ml Bottle26.03 USD
Ciprofloxacin HCl 0.3% Solution 5ml Bottle49.2 USD
Ciprofloxacin er 1000 mg tablet11.16 USD
Ciprofloxacin er 500 mg tablet9.8 USD
Ciprofloxacin hcl 100 mg tablet4.17 USD
Ciprofloxacin hcl 250 mg tablet4.59 USD
Ciprofloxacin hcl 500 mg tablet5.59 USD
Ciprofloxacin hcl 750 mg tablet5.65 USD
Ciprofloxacin hcl powder1.29 USD
Ciprofloxacin-Ciproflox HCl 1000 mg 24 Hour tablet11.6 USD
Ciprofloxacin-Ciproflox HCl 500 mg 24 Hour tablet10.19 USD
Ciprofloxacn-d5w 200 mg/100 ml0.03 USD
Floxin 200 mg tablet6.6 USD
Floxin 300 mg tablet5.61 USD
Floxin 400 mg tablet9.55 USD
Floxin Otic 0.3% Solution 10ml Bottle142.91 USD
Floxin Otic 0.3% Solution 5ml Bottle86.49 USD
Floxin otic singles4.28 USD
Injectable; Injection; Ciprofloxacin 10 mg / ml
Injectable; Injection; Ciprofloxacin 2 mg / ml
Ocuflox 0.3% Solution 10ml Bottle106.09 USD
Ocuflox 0.3% Solution 5ml Bottle57.32 USD
Ocuflox 0.3% eye drops11.35 USD
Pms-Ciprofloxacin 0.3 % Solution1.18 USD
ProQuin XR 3 500 mg 24 Hour tablet Disp Pack39.99 USD
ProQuin XR 500 mg 24 Hour tablet11.18 USD
Proquin xr 500 mg tablet12.18 USD
Tablets; Oral; Ciprofloxacin Hydrochloride 250 mg
Tablets; Oral; Ciprofloxacin Hydrochloride 500 mg
Tablets; Oral; Ciprofloxacin Hydrochloride 750 mg

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Ciprofloxacin destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Ciprofloxacin Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Ciprofloxacin pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."CIPROFLOXACIN (CIPROFLOXACIN HYDROCHLORIDE) TABLET, FILM COATED [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."CIPROFLOXACIN TABLET, FILM COATED [BRYANT RANCH PREPACK]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. Dailymed."CIPROFLOXACIN; DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Ciprofloxacin?

Depending on the reaction of the Ciprofloxacin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Ciprofloxacin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Ciprofloxacin addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sDrugs.com conducted a study on Ciprofloxacin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Ciprofloxacin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Ciprofloxacin useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sDrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

One visitor reported price estimates

What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?
The report given by the sDrugs.com website users shows the following figures about several people who felt the medicine Ciprofloxacin is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
Visitors%
Expensive1
100.0%

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Ciprofloxacin drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Ciprofloxacin is mentioned below.
Visitors%
Once in a day1
100.0%

Four visitors reported doses

What is the dose of Ciprofloxacin drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
201-500mg2
50.0%
101-200mg1
25.0%
1-5mg1
25.0%

Three visitors reported time for results

What is the time duration Ciprofloxacin drug must be taken for it to be effective or for it to reduce the symptoms?
Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sDrugs.com website users needed 3 days to notice the result from using Ciprofloxacin drug. The time needed to show improvement in health condition after using the medicine Ciprofloxacin need not be same for all the users. It varies based on other factors.
Visitors%
3 days1
33.3%
1 week1
33.3%
5 days1
33.3%

Two visitors reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Ciprofloxacin drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
After food1
50.0%
With a meal1
50.0%

Two visitors reported age

Visitors%
16-292
100.0%

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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