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DRUGS & SUPPLEMENTS
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Binozyt
What is the dose of the medication you are taking? |
Binozyt uses
Pharmacological action
Binozyt is a macrolide antibiotic of azalides group. Binozyt inhibits RNA-dependent protein synthesis of sensitive microorganisms.
It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. ; gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.
Pharmacokinetics
Binozyt rapidly absorbed from the gastrointestinal tract. Ingestion reduces the absorption of Binozyt. Cmax in plasma is reached after 2-3 hours. This medicine rapidly distributed in tissues and biological fluids. 35% of the Binozyt is metabolized in the liver by demethylation. More than 59% is excreted in the bile in unchanged form, about 4.5% in the urine in unchanged form.
Why is Binozyt prescribed?
Infectious-inflammatory diseases caused by microorganisms susceptible to Binozyt, including bronchitis, pneumonia, infections of skin and soft tissue, otitis media, sinusitis, pharyngitis, tonsillitis, gonorrheal and non gonorrheal urethritis and / or cervicitis, Lyme disease.
Dosage and administration
Dosage of Binozyt is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.
Binozyt side effects, adverse reactions
Digestive system: nausea, vomiting, flatulence, diarrhea, abdominal pain, transient elevation of liver enzymes, rarely - cholestatic jaundice.
Allergic reactions: rarely - a skin rash, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Dermatological reactions: rarely - photosensitization.
CNS: dizziness, headache, rarely - drowsiness, weakness.
Hematopoietic system: rarely - leukopenia, neutropenia, thrombocytopenia.
Cardiovascular system: rarely - chest pain.
Urogenital system: vaginitis, rarely - candidiasis, nephritis, increased residual nitrogen urea.
Other: rarely - hyperglycemia, arthralgia.
Contraindications
Hypersensitivity to Binozyt and other macrolide antibiotics.
Using during pregnancy and breastfeeding
Binozyt crosses the placental barrier. Use in pregnancy only in cases where the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary to use Binozyt in the lactation period should solve the issue of termination of breastfeeding.
Special instructions
Binozyt not recommended for use in patients with compromised liver function.
Binozyt uses with careful with impaired renal function.
This medication should be taken at least 1 hour before or 2 hours after eating or taking of antacids.
Binozyt drug interactions
Simultaneous administration of Binozyt with these drugs and medications may has followed effects:
Binozyt pharmaceutical active ingredients containing related brand and generic drugs:
Binozyt available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.