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DRUGS & SUPPLEMENTS
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Beathorphan
When are you taking this medicine? |
Beathorphan uses
Pharmacological action
Beathorphan is an antitussive medication. Inhibiting the excitability of the cough center this medicine suppresses the cough of any origin. Beathorphan has not addiction effects and it has no analgesic and hypnotic action. Beathorphan starts to act after 10-30 minutes after oral administration, the duration of therapeutic action: 5-6 hours for adults and 6-9 hours for children. Beathorphan is an optical isomer of levomethorphan which is similar to morphine. Due to optical isomerism this drug has no opioid effects. Beathorphan used mainly for replacement of codeine as a cough suppressant. In addition to the cough suppressant this medication is used in medicine for diagnostic purposes and may be useful in various cases - from seizures to heroin addiction treatment, some chronic neurodegenerative diseases. These include amyotrophic lateral sclerosis (Charcot's disease), disease of "mad cow and other prion diseases. Beathorphan has also been used for the treatment of mental retardation, Parkinson's disease, in the treatment of lung and other cancers and to prevent tissue rejection in transplantation because of the (poorly known) effects of sigma ligands on tumor cells and immune system.
Pharmacokinetics
After oral administration Beathorphan is completely absorbed from the gastrointestinal tract. Cmax of Beathorphan in plasma is reached after 2 h. This medication biotransformes in the liver. Up to 45% of this drug is excreted by kidneys and there was considerable individual variation in rates of excretion of individual metabolites.
Why is Beathorphan prescribed?
Dry cough of different etiology.
Dosage and administration
For adults and children over 12 years Beathorphan prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Beathorphan side effects, adverse reactions
Drowsiness, nausea, dizziness.
Beathorphan contraindications
Bronchial asthma, bronchitis, simultaneous reception of mucolytic.
Using during pregnancy and breastfeeding
During pregnancy and lactation (breastfeeding) Beathorphan prescribed with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or child.
Special instructions
With carefully administered Beathorphan with impaired liver function.
Beathorphan drug interactions
MAO inhibitors when administered simultaneous with Beathorphan may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Beathorphan may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Beathorphan in case of emergency / overdose
Symptoms: excitement, dizziness, respiratory depression, impaired consciousness, decreased blood pressure, tachycardia, muscle hypertonicity, ataxia.
Treatment: mechanical ventilation, symptomatic agents.
Beathorphan pharmaceutical active ingredients containing related brand and generic drugs:
Beathorphan available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.