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Atomoxetine uses

Pharmacological action

Atomoxetine is a centrally acting sympathomimetic. This medication is highly selective potent inhibitor of presynaptic norepinephrine transporters. Atomoxetine has minimal affinity to the other noradrenergic receptors or to other transporters or receptors of neurotransmitters.

This drug does not apply to psychostimulants and it is not a derivative of amphetamine. In clinical trials there were not noted of increase symptoms or any adverse events associated with withdrawal syndrome.


After oral administration Atomoxetine is quickly and almost completely absorbed, reaching a Cmax in the plasma of approximately 1-2 hours. This medication is well distributed in the body. It has a high affinity for plasma proteins, primarily to albumin. The average T1/2 of Atomoxetine after oral administration is 3.6 hours in patients with severe metabolism and 21 hours in patients with decreased metabolism. This drug is mainly excreted in the urine.

Why is Atomoxetine prescribed?

Attention Deficit Hyperactivity Disorder in children 6 years and older, adolescents and adults.

Dosage and administration

Atomoxetine is taken orally regardless of the meal or during a meal, as a single daily dose in the morning. In the case of adverse reactions while taking the drug 1 time / day, patients can be recommended to receive doses 2 times / day, dividing the dose by levee and reception late in the afternoon or early evening.

For children and adolescents weighing 70 kg the recommended initial daily dose is about 0.5 mg / kg and increased to a therapeutic daily dose of about 1.2 mg / kg no sooner than 3 days. In the absence of improvement of the patient's total daily dose may be increased to a maximum dose of 1.8 mg / kg no sooner than 2-4 weeks after starting treatment. The recommended maintenance dose is approximately 1.2 mg / kg / day. The recommended maximum daily dose is 1.8 mg / kg or 120 mg.

For children and adolescents weighing over 70 kg and adults the recommended initial daily dose is 40 mg and increased to a therapeutic daily dose of 80 mg no earlier than 3 days. In the absence of improvement of the patient's total daily dose may be increased to a maximum dose of 120 mg did not earlier than 2-4 weeks after starting treatment. The recommended maintenance dose is 80 mg. The recommended maximum daily dose is 120 mg.


Atomoxetine side effects, adverse reactions

Side effects in patients with poor metabolism: loss of appetite, insomnia, impaired quality of sleep, enuresis, poor mood, tremor, early morning awakening, conjunctivitis, syncope, mydriasis.

Digestive system: very often - loss of appetite, dry mouth, nausea; often - abdominal pain, constipation, dyspepsia, flatulence.

CNS: very often - insomnia; often - early morning awakening, decreased libido, insomnia, dizziness, impaired sleep quality, sinus headache, drowsiness.

Cardiovascular system: often - hot flashes of blood, palpitations, tachycardia; sometimes - the feeling of coldness in the lower extremities; very rare - peripheral vascular reactions and / or Raynaud's syndrome and Raynaud's syndrome risk of relapse.

Urinary system: often - difficulty urinating, urinary retention.

Reproductive system: often - dysmenorrhea, abnormal ejaculation, lack of ejaculation, erectile dysfunction, erectile dysfunction, menstrual disorders, impaired orgasm, prostate; very rare - according to spontaneous reports, a painful or prolonged erection.

Dermatological reactions: often - dermatitis, excessive sweating.

Other: often - fatigue, chills, weight loss.

Atomoxetine contraindications

The simultaneous use of MAO inhibitors, angle-closure glaucoma, increased sensitivity to Atomoxetine.

Using during pregnancy and breastfeeding

The use of Atomoxetine pregnancy and lactation is possible only if the expected benefit of therapy to the mother far outweighs the potential risk to the fetus or infant.

It is not known whether Atomoxetine excreted in breast milk in humans.

Special instructions

Use Atomoxetine with caution in patients with hypertension, tachycardia, with cardiovascular disease, violation of cerebral circulation, as well as any condition which may lead to hypotension, since reported cases of orthostatic hypotension.

This medication can cause arterial hypertension in patients with end-stage renal disease.

ADHD symptoms as impaired attention and hyperactivity may been showed as impairment of concentration, distractibility, excessive restlessness, impulsiveness, disorganization, restlessness, and other similar conduct disorder. The diagnosis of ADHD must meet the criteria for ICD-10.

In clinical studies in children and adolescents during treatment with this medicine there was increased a risk of suicidal thoughts.

In rare cases, patients taking Atomoxetine observed allergic reactions - rashes, angioedema, urticaria.

This drug should not be used for at least 2 weeks after discontinuation of MAO inhibitors. Treatment of MAO inhibitors should not be initiated within 2 weeks after discontinuation of Atomoxetine.

Many patients taking atomoksetin, there was some increase in heart rate and / or increased blood pressure (an average of < 5 mm Hg). In most cases, these changes were not clinically significant effect. Also there were cases of orthostatic hypotension.

In patients with manifestations of jaundice or laboratory parameters identified which indicate liver dysfunction this medication should be abolished.

Patients (especially children and teenagers) who are receiving treatment for ADHD should be monitored for the onset of aggressive behavior or hostility.

Patients receiving Atomoxetine require supervision due to risk of occurrence of the following symptoms: anxiety, agitation, panic attacks, insomnia, irritability, impulsivity, akathisia, hypomania and mania.

Atomoxetine drug interactions

When this drug applied simultaneously with agonists of beta2-adrenergic receptors it may been increase their effects on the cardiovascular system (this combination should be used with caution).

In patients with severe metabolism CYP2D6 inhibitors increase the content of CYP2D6 Atomoxetine in plasma at steady state to a level similar to that in patients with decreased metabolism of CYP2D6.

When Atomoxetine used with drugs affecting blood pressure it may been changes in blood pressure.

Atomoxetine in case of emergency / overdose

Symptoms: drowsiness, agitation, hyperactivity, behavioral disorders, gastrointestinal dysfunction, mydriasis, tachycardia, dry mouth, seizures.

Treatment: gastric lavage, activated charcoal, control of the heart and vital signs, ventilation, symptomatic and supportive therapy. Hemodialysis is ineffective.


Atomoxetine pharmaceutical active ingredients containing related brand and generic drugs:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.

Atomoxetine available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Capsules; Oral; Atomoxetine Hydrochloride 10 mg
Capsules; Oral; Atomoxetine Hydrochloride 100 mg
Capsules; Oral; Atomoxetine Hydrochloride 18 mg
Capsules; Oral; Atomoxetine Hydrochloride 25 mg
Capsules; Oral; Atomoxetine Hydrochloride 40 mg
Capsules; Oral; Atomoxetine Hydrochloride 60 mg
Capsules; Oral; Atomoxetine Hydrochloride 80 mg
Strattera 10 mg capsule5.84 USD
Strattera 100 mg capsule6.83 USD
Strattera 18 mg capsule6.03 USD
Strattera 25 mg capsule5.85 USD
Strattera 40 mg capsule6.43 USD
Strattera 60 mg capsule6.43 USD
Strattera 80 mg capsule6.94 USD


Atomoxetine destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.

Atomoxetine Anatomical Therapeutic Chemical codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.

Atomoxetine pharmaceutical companies:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.



  1. Dailymed."STRATTERA (ATOMOXETINE HYDROCHLORIDE) CAPSULE STRATTERA (ATOMOXETINE HYDROCHLORIDE) KIT [ELI LILLY AND COMPANY". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."STRATTERA (ATOMOXETINE) CAPSULE [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "Atomoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Atomoxetine?

Depending on the reaction of the Atomoxetine after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Atomoxetine not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Atomoxetine addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.



sDrugs.com conducted a study on Atomoxetine, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Atomoxetine consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Atomoxetine drug as prescribed by the doctor?

Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sDrugs.com website users about the frequency of taking the drug Atomoxetine is mentioned below.
Once in a day1

One visitor reported doses

What is the dose of Atomoxetine drug you are taking?
According to the survey conducted among sDrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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