DRUGS & SUPPLEMENTS

Apurol

Name: Apurol drug & pharmaceuticals. Apurol available forms, doses, prices
Creator: sdrugs.com
Published: 2021-11-11T10:10:10+00:00

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Apurol uses

Pharmacological action
Pharmacokinetics
Why is Apurol prescribed?
Dosage and administration
Apurol side effects, adverse reactions
Apurol contraindications
Using during pregnancy and breastfeeding
Special instructions
Apurol drug interactions
Apurol in case of emergency / overdose
Apurol reviews

Pharmacological action

Apurol is a medication that violates the synthesis of uric acid. This drug is a structural analog of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine to uric acid. This is due to decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing uric acid deposits and prevents their formation in tissues and kidney. Apurol increases urinary excretion of hypoxanthine and xanthine.

Pharmacokinetics

After oral administration Apurol is almost entirely absorbed from the gastrointestinal tract. This medication is metabolized to form alloxantin, which retains the ability to sufficiently long to inhibit xanthine oxidase. C_max of Apurol in the blood plasma is reached after an average of 1.5 h, alloxantin - in 4.5 h after a single dose.

T_1/2 of Apurol is 1-2 hours, alloxantin - about 15 hours. About 20% of the administered dose is excreted through the intestines and the rest by kidneys.

Why is Apurol prescribed?

Treatment and prevention of gout and hyperuricemia different genesis (including in conjunction with nephrolithiasis, renal failure, uric acid nephropathy). Recurrent mixed calcium oxalate kidney stones if hyperuricosuria. Increased production of urate due to enzyme disorders. Prevention of acute kidney disease in cytostatic and radiotherapy of tumors and leukemia, as well as full medical starvation.

Dosage and administration

The dosing regimen of Apurol is set individually under the control of concentrations of urate and uric acid in blood and urine. The ora ldose for adults is 100-900 mg / day depending on the severity of the disease. The frequency of admission is 2-4 times / day after a meal. For children under the age of 15 years - 10-20 mg / kg / day or 100-400 mg / day.

Maximum doses: if renal dysfunction - 100 mg / day. Increasing the dose is possible when on the background of the therapy remains an increased concentration of urate in the blood and urine.

Apurol side effects, adverse reactions

Cardio-vascular system: in single cases - hypertension, bradycardia.

Digestive system: possible dyspepsia (including nausea, vomiting), diarrhea, transient increase of transaminases in blood serum; rarely - hepatitis, in single cases - stomatitis, liver function (transient increase of transaminases and alkaline phosphatase), steatorrhea.

CNS and peripheral nervous system: in single cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, seizures, neuropathy, visual impairment, cataracts, changes in the papilla of the optic nerve, disorders of taste sensations.

Hemopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function).

Urinary system: rarely - interstitial nephritis, in single cases - edema, uremia, hematuria.

Endocrine system: in single cases - sterility, impotence, gynecomastia, diabetes.

Metabolism: in single cases - hyperlipidemia.

Allergic reactions: skin rash, redness, itching; in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome.

Dermatological reactions: in rare cases - furunculosis, alopecia, discoloration of hair.

Apurol contraindications

Pronounced liver function and / or renal disease, pregnancy, lactation, hypersensitivity to Apurol.

Using during pregnancy and breastfeeding

Apurol is contraindicated during pregnancy and lactation.

Category effects on the fetus by FDA - C.

Special instructions

It is necessary to maintain urine output of at least 2 liters a day and a neutral or slightly alkaline reaction of urine, because it prevents the precipitation of urate and the formation of concretions. You should not begin therapy with Apurol until complete relief of acute attack of gout; during the first month of treatment is recommended prophylactic administration of NSAIDs or colchicine; in the case of an acute attack of gout during therapy was added to the anti-inflammatory drugs. If impaired renal and liver function (increased risk of side effects), the dose is decreased. First 6-8 weeks of treatment need regular liver function tests, and blood diseases require regular laboratory monitoring.

When a skin rash this drug is overturned, after the disappearance of the not copious rash there are possible a reappointment of the drug in its treatment of relapsed immediately terminate.

Use of azathioprine or 6-mercaptopurine on the background of Apurol permits a 4-fold reduction in their doses. This medication combined with a care with vidarabine.

Apurol drug interactions

With the simultaneous administration Apurol increases the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic agents.

Uricosuric medicines and salicylates in high doses reduce the activity of Apurol Biogaran.

With the simultaneous administration of Apurol and cytostatics there is often manifested myelotoxic effect than when applied separatively.

With the simultaneous administration of this drug and azathioprine or mercaptopurine it is observed accumulation of the latter in the body, because in connection with the activity of xanthine oxidase inhibition with Apurol necessary to biotransformation of drugs, slowing their metabolism and elimination.

Apurol in case of emergency / overdose

Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria.

Treatment: forced diuresis, hemodialysis and peritoneal dialysis.

Apurol pharmaceutical active ingredients containing related brand and generic drugs:

Allopurinol

Apurol available forms, composition, doses:

Tablets; Oral; Allopurinol 100 mg

Apurol destination | category:

Human:
Hyperuricemia and gout preparations

Apurol Anatomical Therapeutic Chemical codes:

M04AA01 - Allopurinol

Apurol pharmaceutical companies:

References

Dailymed."ALLOPURINOL TABLET [PD-RX PHARMACEUTICALS, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Dailymed."ALLOPURINOL; LESINURAD: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
"allopurinol". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Apurol?

Depending on the reaction of the Apurol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Apurol not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Apurol addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sdrugs.com conducted a study on Apurol, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Apurol consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.