DRUGS & SUPPLEMENTS
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Andepin is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Andepin is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Andepin apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Andepin does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.
Andepin absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Andepin easily penetrates through the BBB.
Andepin metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.
T1/2 of Andepin is 2-3 days, norfluoxetine - 7-9 days.
Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.
The initial dose of Andepin is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.
The maximum oral daily dose for adults is 80 mg.
CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.
Digestive system: diarrhea, nausea.
Metabolism: increased sweating, hypoglycemia, hyponatremia.
Reproductive system: decreased libido.
Allergic reactions: skin rash, itching.
Other: pain in joints and muscles, shortness of breath, increased body temperature.
Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Andepin.
Andepin is contraindicated during pregnancy and lactation.
Andepin should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.
Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Andepin increases the risk of epileptic seizures.
With the simultaneous application of Andepin and electroconvulsive therapy may develop prolonged seizures.
Andepin can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Andepin before therapy MAO inhibitors should not be less than 5 weeks.
Elderly patients need correction of dosing regimen.
Safety of Andepin in children has not been established.
During the period of treatment it needed to avoid use alcohol.
During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.
Simultaneous administration of Andepin with:
Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Andepin (in combination with maprotiline, codeine, temazepam).
Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.
Depending on the reaction of the Andepin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Andepin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.Is Andepin addictive or habit forming?
Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
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The information was verified by Dr. Rachana Salvi, MD Pharmacology