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DRUGS & SUPPLEMENTS
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Amvey
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Amvey uses
Pharmacological action
Amvey is a sleeping drug from group of cyclopyrrolone derivatives. This drug is "non benzodiazepine" agonist of benzodiazepine receptors. Amvey also has sedative, anxiolytic, muscle-relaxing center, anticonvulsant and amnesic properties. Like a derivative of benzodiazepine Amvey enhances GABA-ergic processes in the brain, interacting with the benzodiazepine receptors, as a result of the increased sensitivity of GABA-receptors to the neurotransmitter. However, Amvey apparently interacts with other parts of the benzodiazepine receptor than benzodiazepines.
Amvey reduced sleep time, reduces the number of nighttime awakenings, increases total sleep time. This medication almost has no effect on sleep structure, does not reduce significantly the amount of REM sleep. Consequences of the phenomenon of waking up are missing or expressed little. Readmission Amvey are not accompanied by cumulation.
Pharmacokinetics
Amvey rapidly and completely absorbed from the gastrointestinal tract. Cmax achieved within 1-3 hours. Amvey easily passes through gistogematicheskie barriers including the BBB and it is distributed in organs and tissues including brain. T1/2 is 5.5-6 hours, not accumulates.
Why is Amvey prescribed?
Sleep disturbance, transient, situational or chronic insomnia; sleep disturbances in mental disorders, bronchial asthma with nocturnal seizures (in combination with single dose daily dose of theophylline).
Dosage and administration
The average therapeutic dose of Amvey is 7.5 mg orally at night, in cases of severe insomnia the dose can be increased up to 15 mg. In elderly patients, as well as abnormal liver function is used 3.75 mg.
Amvey side effects, adverse reactions
Digestive system: a feeling of bitter or metallic taste in the mouth, dry mouth, nausea, and vomiting.
CNS: dizziness, headache, drowsiness, confusion, anterograde amnesia, hallucinations, nightmares.
Dermatologic reactions: skin rash.
Amvey contraindications
Severe respiratory failure, pregnancy, lactation, children and teens under 15 years old, hypersensitivity to Amvey.
Using during pregnancy and breastfeeding
Amvey is contraindicated during pregnancy (especially in I and III trimester) and lactation (breastfeeding). If a woman uses Amvey in III trimester of pregnancy there are possible violations of the nervous system in the newborn, the emergence of withdrawal syndrome. If the woman is prescribed by a doctor took Amvey immediately prior to labor and delivery, it needs a constant medical surveillance for the newborn. At the time of treatment it should be stoped breastfeeding (zopiclone penetrates into breast milk).
Special instructions
With caution use in patients with severe liver failure.
Risk of drug dependence is minimal if the duration of Amvey did not exceed 4 weeks. However, the potential danger of Amvey dependence to exist.
During the period of treatment patients should to exclude the use of alcohol.
On the next day after taking the drug it should be cautious to drive and operate machinery.
Amvey drug interactions
Simultaneous administration of Amvey with trimipramine reduces the concentration of trimipramine in plasma and its effect.
Amvey increases the influence of CNS depressants.
Amvey in case of emergency / overdose
Symptoms: CNS depression of varying severity (from drowsiness to loss of consciousness).
Treatment: gastric lavage, taking activated charcoal, if necessary - symptomatic therapy. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital). Hemodialysis is ineffective.
Amvey pharmaceutical active ingredients containing related brand and generic drugs:
Amvey available forms, composition, doses:
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.