Amplus Injections

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Amplus Injections uses

Amplus Injections consists of Ampicillin Sodium, Cloxacillin Sodium.

Ampicillin Sodium:


Pharmacological action

Amplus Injections is an antibiotic of semisynthetic broad-spectrum penicillin group. This medication has a bactericidal effect by suppressing the synthesis of bacterial cell walls. Amplus Injections (Ampicillin Sodium) is active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp., Enterococcus spp., Listeria monocytogenes; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Amplus Injections (Ampicillin Sodium) destroyed by penicillinase. This drug is acid-resistant.

Pharmacokinetics

After oral administration Amplus Injections (Ampicillin Sodium) is well absorbed from the gastrointestinal tract. This medicine is distributed in most organs and tissues; crosses the placental barrier, poorly penetrates the BBB. When inflammation of the meninges, BBB permeability increases dramatically. 30% of Amplus Injections (Ampicillin Sodium) is metabolized in the liver. This medication is excreted in the urine and bile.

Why is Amplus Injections prescribed?

Infectious-inflammatory diseases caused by organisms susceptible to Amplus Injections (Ampicillin Sodium): including ear infections, throat, nose, odontogenic infections, bronchopulmonary infections, acute and chronic urinary tract infections, gastrointestinal infections (including salmonella, cholecystitis), gynecological infections, meningitis, endocarditis, septicemia, sepsis, rheumatic fever, erysipelas, scarlet fever, infections of skin and soft tissues.

Dosage and administration

The dosing regimen of Amplus Injections is set individually depending on the severity, localization of infection and sensitivity of the pathogen.

For adults for oral administration a single dose of this medication is 250-500 mg, the multiplicity of the reception is 4 times / day. The dose for children weighing up to 20 kg is 12.5-25 mg / kg every 6 hours.

For IV and IM using the single dose for adults is 250-500 mg every 4-6 hours; for children the single dose is 25-50 mg / kg.

The duration of treatment depends on the localization of infection and features of the disease.

The maximum oral daily dose for adults is 4 g, for IM and IV administration - 14 g.

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Amplus Injections (Ampicillin Sodium) side effects, adverse reactions

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, extremely rare - anaphylactic shock.

Digestive system: nausea, vomiting.

The effects caused by chemotherapeutic action: oral candidiasis, vaginal candidiasis, intestinal dysbiosis, colitis caused by Clostridium difficile.

Amplus Injections contraindications

Infectious mononucleosis, lymphatic leukemia, increased sensitivity to Amplus Injections (Ampicillin Sodium) and other penicillins, abnormal liver function.

Using during pregnancy and breastfeeding

Perhaps the use of Amplus Injections during pregnancy if it may be needed. Amplus Injections (Ampicillin Sodium) is excreted in breast milk in low concentrations. If necessary to use Amplus Injections (Ampicillin Sodium) in the lactation period it should be solved the issue of termination of breastfeeding.

Category effects on the fetus by FDA - B.

Special instructions

In the course of treatment with Amplus Injections (Ampicillin Sodium) there is need the regular control of renal function, liver and peripheral blood picture. Patients with impaired renal function requires correction dosing regimen in accordance with the values of CCr.

When used in high doses in patients with renal insufficiency it may be toxic effects on the CNS.

For using of Amplus Injections (Ampicillin Sodium) in patients with bacteremia (sepsis) it can be bacteriolysis reaction (Jarisch-Herxheimer reaction).

Amplus Injections drug interactions

Simultaneous administration of Amplus Injections (Ampicillin Sodium) with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) there is manifested synergism; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amplus Injections (Ampicillin Sodium) enhances the effect of indirect anticoagulants by inhibiting the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.

Amplus Injections (Ampicillin Sodium) decreases the effect of drugs in the process of metabolism which produce PABA.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of Amplus Injections (Ampicillin Sodium) which may be accompanied by an increase in its concentration in blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of Amplus Injections (Ampicillin Sodium) Upha Corporation. Ascorbic acid increases the absorption of Amplus Injections (Ampicillin Sodium).

Amplus Injections (Ampicillin Sodium) decreases the effectiveness of oral contraceptives.

Amplus Injections in case of emergency / overdose

Symptoms: the toxic effect on the central nervous system (especially in patients with renal insufficiency), nausea, vomiting, diarrhea, impaired water and electrolyte balance (as a consequence of vomiting and diarrhea).

Treatment: gastric lavage, activated charcoal, saline laxatives, a maintain of water and electrolyte balance, symptomatic therapy. This drug is derived by means of hemodialysis.

Cloxacillin Sodium:



NADA 055-058, Approved by FDA

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description:

Amplus Injections (Cloxacillin Sodium) (cloxacillin benzathine) for Intramammary Infusion into the Dry Cow is a product which provides bactericidal activity against gram-positive bacteria. The active agent, Amplus Injections (Cloxacillin Sodium) benzathine, is a sparingly soluble salt of the semisynthetic penicillin, Amplus Injections (Cloxacillin Sodium). Amplus Injections (Cloxacillin Sodium) is a derivative of 6-aminopenicillanic acid, and therefore is chemically related to other penicillins. It has, however, the antibacterial properties described below, which distinguish it from certain other penicillins.

Each 10 mL disposable syringe contains Amplus Injections (Cloxacillin Sodium) benzathine equivalent to 500 mg of Amplus Injections (Cloxacillin Sodium) activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.

Storage:

Do not store above 25°C (77°F). Do not freeze.

Action:

In the non-lactating mammary gland, Amplus Injections (Cloxacillin Sodium) (cloxacillin benzathine) provides bactericidal levels of the active antibiotic, Amplus Injections (Cloxacillin Sodium), for a prolonged period of time. This prolonged activity is due to the low solubility of the Amplus Injections (Cloxacillin Sodium) benzathine and to the slow-release oil-gel base. This prolonged contact between the antibiotic and the pathogenic organism enhances the probability of a bacteriological cure.

Amplus Injections (Cloxacillin Sodium) is not destroyed by the enzyme, penicillinase, and therefore, is active against penicillin-resistant strains of Staphylococcus aureus. It is also active against non-penicillinase-producing Staphylococcus aureus as well as Streptococcus agalactiae.

The class disc, Methicillin 5 mcg, should be used to estimate the in vitro susceptibility of bacteria to Amplus Injections (Cloxacillin Sodium).

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Indications:

For the treatment of mastitis in dairy cows during the dry period.

Amplus Injections (Cloxacillin Sodium) has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus including penicillin-resistant strains.

Treatment of the dry cow with Amplus Injections (Cloxacillin Sodium) is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated attacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms.

Dosage for Dry Cows:

Infuse the contents of one syringe (10 mL) into each quarter following the last milking. See Directions for Use.

Directions for Use:

Amplus Injections (Cloxacillin Sodium) (cloxacillin benzathine) is for use in dry cows only. Administer immediately after the last milking. Use no later than 30 days prior to calving.

Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.

Amplus Injections (Cloxacillin Sodium) is packaged with the Opti-Sert® Protective Cap.

For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3–4 mm of the syringe tip.

For full insertion: Remove protective cap to expose the full length of the syringe tip.

Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.

Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.

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Precautions:

Because it is a derivative of 6-aminopenicillanic acid, Amplus Injections (Cloxacillin Sodium) has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.

Residue Warnings:

1. For use in dry cows only.

2. Not to be used within 30 days of calving.

3. Any animal infused with this product must not be slaughtered for food until 30 days after the latest infusion.

How Supplied:

Amplus Injections (Cloxacillin Sodium) (cloxacillin benzathine) Intramammary Infusion is supplied as 10 mL syringes containing 500 mg of Amplus Injections (Cloxacillin Sodium) activity per syringe. One display carton contains 12 syringes. One pail contains 144 syringes.

NDC 0010-4720-01 - 10 mL syringe

NDC 0010-4720-02 - 12 syringes

NDC 0010-4720-03 - 144 syringes

Opti-Sert is a registered trademark of Zoetis W LLC - used under license.

Amplus Injections (Cloxacillin Sodium) is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.

© 2014 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.

Made in Italy

Manufactured for:

Boehringer Ingelheim Vetmedica, Inc.

St. Joseph, MO 64506 U.S.A.

51729292

472001-03

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Amplus Injections pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Amplus Injections available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


Amplus Injections destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Amplus Injections Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Amplus Injections pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [SANDOZ INC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."CLOXACILLIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. Dailymed."AMPICILLIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Amplus Injections?

Depending on the reaction of the Amplus Injections after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Amplus Injections not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Amplus Injections addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Amplus Injections, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Amplus Injections consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

One visitor reported useful

How is the drug Amplus Injections useful in reducing or relieving the symptoms? How useful is it?
According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
Visitors%
Useful1
100.0%

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Amplus Injections drug as prescribed by the doctor?

Few medications can be taken Twice in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Amplus Injections is mentioned below.
Visitors%
Twice in a day1
100.0%

Visitor reported doses

No survey data has been collected yet

Visitor reported time for results

No survey data has been collected yet

Visitor reported administration

No survey data has been collected yet

Visitor reported age

No survey data has been collected yet

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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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