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Medication: Adprazole

Adprazole uses

  1. ACTIVE INGREDIENT (IN EACH TABLET)
  2. PURPOSE
  3. USE
  4. WARNINGS
  5. DIRECTIONS
  6. OTHER INFORMATION
  7. INACTIVE INGREDIENTS
  8. QUESTIONS?
  9. PRINCIPAL DISPLAY PANEL - 14 TABLET CARTON

Pharmacological action

Adprazole is an inhibitor of H+ K+ ATPase. This medication inhibits the activity of H+-K+-ATPase in gastric parietal cells and thus blocks the final stage of hydrochloric acid secretion. This leads to a reduction in basal and stimulated secretion, regardless of the nature of the stimulus. Due to the reduction of acid secretion Adprazole reduces or normalizes the effects of acid in the esophagus in patients with reflux esophagitis.

Adprazole has a bactericidal effect on Helicobacter pylori. Eradication of H. pylori when Adprazole used with antibiotics allows to quickly arrest the symptoms, to take a high degree of healing of damaged mucosa and persistent long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract.

Pharmacokinetics

After oral administration Adprazole is rapidly absorbed from the gastrointestinal tract. This drug penetrates the parietal cells of gastric mucosa. Plasma protein binding is about 95%. Adprazole is biotransformed in the liver. Excreted by the kidneys - 72-80%, in the faeces - about 20%. T1/2 is 0.5-1 h. In patients with chronic liver diseases T1/2 increases up to 3 hours.

Why is Adprazole prescribed?

Gastric ulcer and duodenal ulcer in acute phase (including associated with Helicobacter pylori), reflux esophagitis, Zollinger-Ellison syndrome, erosive and ulcerative lesions of gastric and duodenal ulcers associated with taking NSAIDs.

Dosage and administration

The dosing regimen of Adprazole is individual. When this medication is administered orally of the single dose is 20-40 mg. The daily dose is 20-80 mg, the frequency of use is 1-2 times / day. The duration of treatment is 2-8 weeks.

Adprazole side effects, adverse reactions

Digestive system: rarely - nausea, diarrhea, constipation, abdominal pain, flatulence.

CNS: rarely - headache, dizziness, weakness.

Hemopoietic system: in some cases - anemia, eosinopenia, neutropenia, thrombocytopenia.

Urinary system: in some cases - hematuria, proteinuria.

Musculoskeletal system: in some cases - arthralgia, muscle weakness, myalgia.

Allergic reactions: rarely - skin rash.

Adprazole contraindications

Chronic liver disease, hypersensitivity to omeprazole.

Using during pregnancy and breastfeeding

In the absence of clinical experience with Adprazole it is not recommended to use this drug during pregnancy. If necessary to use during Adprazole lactation it should been solve the issue of termination of breastfeeding.

Category effects on the fetus by FDA - C.

Special instructions

Before the treatment with Adprazole it is necessary to exclude the possibility of a malignant process because Adprazole treatment can mask symptoms and delay the correct diagnosis.

Therapy with Adprazole may affects results of laboratory studies of liver and gastrin concentrations in blood plasma.

Due to lack of experience in clinical application of Adprazole this medicine is not recommended for children.

Adprazole drug interactions

This medication alters the bioavailability of any drug, absorption depends on pH (ketoconazole, iron salts, etc.). Adprazole slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).

Adprazole enhances the action of coumarin and diphenine, does not change - NSAIDs. This drug increases (relative) the concentration of clarithromycin in the blood; may increases the leukopenic and thrombocytopenic effects of depressants hematopoiesis drugs. Substance for intravenous infusion is compatible only with saline and dextrose (using other solvents may decrease the stability of Adprazole due to changes in pH of infusion medium).

Adprazole in case of emergency / overdose

Symptoms: dry mouth, nausea, blurred vision, headache, increased sweating, flushing, tachycardia, drowsiness, confusion.

Treatment: symptomatic, dialysis is ineffective.

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Adprazole pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products:

infoActive ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug. The below information contains the active ingredients of Adprazole.


Adprazole available forms, composition, doses:

infoForm of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease. The below information contains the forms, composition, doses of Adprazole.


Adprazole destination | category:

infoDestination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so. The below information contains the destination, category of Adprazole.


Adprazole indications and usages, anatomical therapeutic chemical and diseases classification codes:

infoA medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code. The below information contains the Indications and usages, anatomical therapeutic chemical and diseases classification codes of Adprazole.


Adprazole pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers:

infoPharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug. The below information contains the information about Pharmaceutical companies and Researchers involved in the development of Adprazole.


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Frequently asked Questions

Can i drive or operate heavy machine after consuming Adprazole?

Depending on the reaction of the Adprazole after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Adprazole not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Adprazole addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

Review

sDrugs.com conducted a study on Adprazole, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Adprazole consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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