Adep

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Adep uses


Pharmacological action

Adep is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Adep is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Adep apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Adep does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.

Pharmacokinetics

Adep absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Adep easily penetrates through the BBB.

Adep metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.

T1/2 of Adep is 2-3 days, norfluoxetine - 7-9 days.

Why is Adep prescribed?

Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.

Dosage and administration

The initial dose of Adep is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.

The maximum oral daily dose for adults is 80 mg.

Adep side effects, adverse reactions

CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.

Digestive system: diarrhea, nausea.

Metabolism: increased sweating, hypoglycemia, hyponatremia.

Reproductive system: decreased libido.

Allergic reactions: skin rash, itching.

Other: pain in joints and muscles, shortness of breath, increased body temperature.

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Adep contraindications

Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Adep.

Using during pregnancy and breastfeeding

Adep is contraindicated during pregnancy and lactation.

Special instructions

Adep should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.

Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Adep increases the risk of epileptic seizures.

With the simultaneous application of Adep and electroconvulsive therapy may develop prolonged seizures.

Adep can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Adep before therapy MAO inhibitors should not be less than 5 weeks.

Elderly patients need correction of dosing regimen.

Safety of Adep in children has not been established.

During the period of treatment it needed to avoid use alcohol.

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Adep drug interactions

Simultaneous administration of Adep with:

  • drugs providing a depressing effect on the central nervous system and with ethanol it is possibly significantly increased inhibitory action on the CNS, as well as increasing the likelihood of developing seizures;
  • MAO inhibitors, furazolidone, procarbazine, tryptophan may develop serotonin syndrome ;
  • Adep inhibits the metabolism of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin, thereby increasing their concentration in serum, increase their therapeutic and side effects;
  • it is possible inhibition of the biotransformation of drugs metabolized with the participation of isoenzyme CYP2D6;
  • hypoglycemic agents may increase their activities;
  • haloperidol, fluphenazine, maprotiline, metoclopramide, perphenazine, pyrathiazine, pimozide, risperidone, sulpiride, trifluoperazine there were describes cases of extrapyramidal symptoms and dystonia; with dextromethorphan - described a case of hallucinations; with digoxin - the case of increasing the concentration of digoxin in plasma;
  • with lithium salts may increase or decrease the concentration of lithium in blood plasma;
  • may increase the concentration of imipramine and desipramine in plasma is 2-10 times (and may persist for 3 weeks after discontinuation of Adep Sanis Health);
  • propofol there was described a case in which spontaneous movements were observed; with phenylpropanolamine - described a case in which were observed dizziness, weight loss, hyperactivity;
  • may increase the effects of flecainide, mexiletine, propafenone, thioridazine, zuclopenthixol. There are reports on the strengthening effects of warfarin in its simultaneous application with Adep.

    Adep in case of emergency / overdose

    Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Adep (in combination with maprotiline, codeine, temazepam).

    Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.

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    Adep pharmaceutical active ingredients containing related brand and generic drugs:

    Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


    Adep available forms, composition, doses:

    Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
    Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
    Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.


    Adep destination | category:

    Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
    Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


    Adep Anatomical Therapeutic Chemical codes:

    A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


    Adep pharmaceutical companies:

    Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
    Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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    References

    1. Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
    2. "fluoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
    3. "fluoxetine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).

    Frequently asked Questions

    Can i drive or operate heavy machine after consuming Adep?

    Depending on the reaction of the Adep after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Adep not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

    Is Adep addictive or habit forming?

    Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

    Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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    Review

    sdrugs.com conducted a study on Adep, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Adep consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

    Visitor reports

    One visitor reported useful

    How is the drug Adep useful in reducing or relieving the symptoms? How useful is it?
    According to the survey conducted by the website sdrugs.com, there are variable results and below are the percentages of the users that say the medicine is useful to them and that say it is not helping them much. It is not ideal to continue taking the medication if you feel it is not helping you much. Contact your healthcare provider to check if there is a need to change the medicine or if there is a need to re-evaluate your condition. The usefulness of the medicine may vary from patient to patient, depending on the other diseases he is suffering from and slightly depends on the brand name.
    Visitors%
    Useful1
    100.0%

    Visitor reported side effects

    No survey data has been collected yet

    Visitor reported price estimates

    No survey data has been collected yet

    One visitor reported frequency of use

    How often in a day do you take the medicine?
    Are you taking the Adep drug as prescribed by the doctor?

    Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Adep is mentioned below.
    Visitors%
    Once in a day1
    100.0%

    Three visitors reported doses

    What is the dose of Adep drug you are taking?
    According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
    Visitors%
    11-50mg2
    66.7%
    51-100mg1
    33.3%

    One visitor reported time for results

    What is the time duration Adep drug must be taken for it to be effective or for it to reduce the symptoms?
    Most chronic conditions need at least some time so the dose and the drug action gets adjusted to the body to get the desired effect. The stastistics say sdrugs.com website users needed 1 day to notice the result from using Adep drug. The time needed to show improvement in health condition after using the medicine Adep need not be same for all the users. It varies based on other factors.
    Visitors%
    1 day1
    100.0%

    One visitor reported administration

    The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Adep drug, before food or after food?
    Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
    Visitors%
    After food1
    100.0%

    Four visitors reported age

    Visitors%
    30-452
    50.0%
    > 601
    25.0%
    46-601
    25.0%

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    The information was verified by Dr. Rachana Salvi, MD Pharmacology

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