Acetaminophen

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Acetaminophen uses


Pharmacological action

Acetaminophen is an analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with inhibition of prostaglandin synthesis, the predominant influence on the thermoregulation center in the hypothalamus, enhances heat transfer.

Why is Acetaminophen prescribed?

Pain weak and moderate intensity of different genesis. Fever in infectious and inflammatory diseases.

Acetaminophen dosage and administration

Oral or rectally adults and adolescents with a body weight over 60 kg is used in a single dose of 500 mg, the multiplicity of admission - up to 4 times / Maximum duration of treatment - 5-7 days.

Maximum dose: single - 1 g, daily - 4 g.

Single dose for oral administration for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg / kg. Single dose rectal in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Multiplicity - 4 at intervals of not less than 4 h. The maximum duration of treatment - 3 days.

Maximum dose: 4 single dose per day.

Acetaminophen side effects, adverse reactions

Digestive system: rarely - dyspepsia; long-term use at high doses - hepatotoxic effects, methemoglobinemia, renal dysfunction and liver, hypochromic anemia. Hemopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis. Allergic reactions: rarely - skin rash, itching, hives.

Contraindications

Chronic active alcoholism, increased sensitivity to Acetaminophen, marked disturbances of liver function and / or kidney disease, anemia, pregnancy.

Using during pregnancy and breastfeeding

Acetaminophen crosses the placental barrier. So far, no observed adverse effects of Acetaminophen on the fetus in humans.

Acetaminophen is excreted in breast milk: the content in milk was 0.04-0.23% of the dose adopted mother.

If necessary, use of Acetaminophen during pregnancy and lactation (breastfeeding) should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or child.

In experimental studies found no embryotoxic, teratogenic and mutagenic action of Acetaminophen.

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Special Instructions

Acetaminophen is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients.

With prolonged use of Acetaminophen is necessary to monitor patterns of peripheral blood and functional state of the liver.

Used for treatment of premenstrual tension syndrome in combination with pamabrom and mepyramine (Histamine H1-receptors blocker).

Acetaminophen Drug Interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of Acetaminophen.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Acetaminophen.

With the simultaneous use of oral contraceptives accelerated excretion of Acetaminophen from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Acetaminophen.

When Acetaminophen applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Acetaminophen. A case of severe toxic liver injury.

Described cases of toxic effects of Acetaminophen, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Acetaminophen, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Acetaminophen and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Acetaminophen may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Acetaminophen and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Acetaminophen, with rifampicin, sulfinpyrazone - may increase clearance of Acetaminophen due to increasing its metabolism in the liver.

At simultaneous application of Acetaminophen with ethinylestradiol increases absorption of Acetaminophen from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Acetaminophen in case of emergency / overdose

At a reception in toxic doses (10-15 g in adults) may develop liver necrosis.

Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms

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Acetaminophen pharmaceutical active ingredients containing related brand and generic drugs:

Active ingredient is the part of the drug or medicine which is biologically active. This portion of the drug is responsible for the main action of the drug which is intended to cure or reduce the symptom or disease. The other portions of the drug which are inactive are called excipients; there role is to act as vehicle or binder. In contrast to active ingredient, the inactive ingredient's role is not significant in the cure or treatment of the disease. There can be one or more active ingredients in a drug.


Acetaminophen available forms, composition, doses:

Form of the medicine is the form in which the medicine is marketed in the market, for example, a medicine X can be in the form of capsule or the form of chewable tablet or the form of tablet. Sometimes same medicine can be available as injection form. Each medicine cannot be in all forms but can be marketed in 1, 2, or 3 forms which the pharmaceutical company decided based on various background research results.
Composition is the list of ingredients which combinedly form a medicine. Both active ingredients and inactive ingredients form the composition. The active ingredient gives the desired therapeutic effect whereas the inactive ingredient helps in making the medicine stable.
Doses are various strengths of the medicine like 10mg, 20mg, 30mg and so on. Each medicine comes in various doses which is decided by the manufacturer, that is, pharmaceutical company. The dose is decided on the severity of the symptom or disease.

Price
Acephen 120 mg suppository0.54 USD
Acephen 325 mg suppository0.54 USD
Acephen 650 mg suppository0.55 USD
Acetaminophen 120 mg suppository0.38 USD
Acetaminophen 160 mg tablet chw0.09 USD
Acetaminophen 325 mg suppository0.44 USD
Acetaminophen 325 mg tablet0.03 USD
Acetaminophen 500 mg caplet0.03 USD
Acetaminophen 500 mg gelcap0.06 USD
Acetaminophen 500 mg geltab0.11 USD
Acetaminophen 500 mg tablet0.11 USD
Acetaminophen 650 mg caplet0.12 USD
Acetaminophen 650 mg suppository0.39 USD
Acetaminophen 80 mg tablet chew0.07 USD
Acetaminophen pm caplet0.08 USD
Acetaminophen powder dense0.07 USD
Apap 325 mg tablet0.07 USD
Apap child's 80 mg tablet chew0.07 USD
Apap jr str 160 mg tablet chew0.12 USD
Apap-butalbital 325-50 tablet0.38 USD
CVS Pharmacy acetaminophen 325 mg tablet0.04 USD
CVS Pharmacy non-aspirin 500 mg caplet0.06 USD
CVS Pharmacy non-aspirin 500 mg tablet0.06 USD
CVS Pharmacy pain relief 500 mg gelcap0.06 USD
CVS Pharmacy pain rlf cool ice caplet0.06 USD
Caplets; Oral; Acetaminophen 325 mg
Caplets; Oral; Acetaminophen 500 mg
Child tylenol cold/cough tablet0.17 USD
Child tylenol cough-runny nose0.05 USD
Child tylenol cough-sore thrt0.05 USD
Child's tylenol 80 mg meltaway0.11 USD
Childrens apap 80 mg tablet chew0.17 USD
Childs tylenol cold-aller susp0.04 USD
Childs tylenol cold-cough susp0.05 USD
Childs tylenol plus cold susp0.04 USD
Childs tylenol plus flu susp0.04 USD
Clemastine fum 2.68 mg tablet0.86 USD
Co-gesic 5-500 tablet0.92 USD
Darvocet A500 100-500 mg tablet1.38 USD
Darvocet a500 tablet1.5 USD
Darvocet-N 100 100-650 mg tablet2.33 USD
Darvocet-N 50 50-325 mg tablet0.73 USD
Darvocet-n 100 tablet1.72 USD
Darvocet-n 50 tablet1.14 USD
Drixoral cold & allergy tablet sa0.4 USD
Drops; Oral; Acetaminophen 80 mg / ml
Elixir; Oral; Acetaminophen 32 mg / ml
Eql pain relief 325 mg tablet0.06 USD
Eql pain relief 500 mg caplet0.1 USD
Eql pain relief 500 mg geltab0.1 USD
Excedrin back & body caplet0.1 USD
Excedrin extra strength caplet0.14 USD
Excedrin menstrual cmplt gelcap0.19 USD
Excedrin migraine caplet0.14 USD
Excedrin migraine geltabs0.15 USD
Excedrin pm 500-38 mg tablet0.08 USD
Excedrin quicktabs0.2 USD
Excedrin sinus headache caplet0.1 USD
Excedrin sinus headache tablet0.14 USD
Excedrin tension headache caplet0.1 USD
Excedrin tension headache tablet0.14 USD
Feverall 120 mg suppository0.8 USD
Feverall 325 mg suppository0.8 USD
Feverall 650 mg suppository0.43 USD
Feverall 80 mg suppository0.8 USD
Genapap 325 mg tablet0.03 USD
Genapap 500 mg tablet0.03 USD
Hydrocodone-apap 10-325 tablet0.7 USD
Hydrocodone-apap 10-500 tablet0.53 USD
Hydrocodone-apap 10-650 tablet0.37 USD
Hydrocodone-apap 10-660 tablet0.61 USD
Hydrocodone-apap 10-750 tablet1.12 USD
Hydrocodone-apap 2.5-500 tablet0.33 USD
Hydrocodone-apap 5-325 tablet0.54 USD
Hydrocodone-apap 7.5-325 tablet0.62 USD
Hydrocodone-apap 7.5-500 tablet0.12 USD
Hydrocodone-apap 7.5-650 tablet0.93 USD
Hydrocodone-apap 7.5-750 tablet0.13 USD
Jr. tylenol 160 mg meltaways0.19 USD
Liquid; Oral; Acetaminophen 80 mg / 5 ml
Mapap 325 mg tablet0.05 USD
Maxapap 325 mg tablet0.01 USD
Maxapap 500 mg caplet0.01 USD
Maxapap 500 mg tablet0.01 USD
Momentum caplet0.23 USD
Non-aspirin 500 mg geltab0.05 USD
Non-aspirin 500 mg tablet0.04 USD
Norco 10-325 mg tablet2.14 USD
Norco 10-325 tablet2.76 USD
Norco 5-325 mg tablet1.43 USD
Norco 5-325 tablet1.19 USD
Norco 7.5-325 mg tablet1.61 USD
Norco 7.5-325 tablet2.77 USD
Pain relief 325 mg tablet0.02 USD
Pain relief 500 mg caplet0.06 USD
Pain relief 500 mg tablet0.03 USD
Pain relief without asa tablet0.05 USD
Pain reliever 160 mg tablet0.08 USD
Pain reliever 325 mg tablet0.06 USD
Pain reliever 500 mg caplet0.09 USD
Pain reliever 500 mg gelcap0.03 USD
Pain reliever 500 mg geltab0.04 USD
Pain reliever 500 mg tablet0.03 USD
Pain reliever w-o asa 325 mg0.02 USD
Phrenilin 50-325 mg tablet1.63 USD
Phrenilin Forte 50-650 mg capsule5.24 USD
Phrenilin forte capsule4.46 USD
Phrenilin tablet1.32 USD
Propoxyphen-apap 100-325 mg tablet2.66 USD
Propoxyphen-apap 100-500 mg tablet1.85 USD
Propoxyphen-apap 100-650 mg tablet0.55 USD
Propoxyphene-apap 50-325 mg tablet0.93 USD
Q-pap ex-str 500 mg tablet0.04 USD
Ra acetaminophen pm caplet0.04 USD
Sedapap 50-650 mg tablet0.92 USD
Soba pain rel 500 mg gelcap0.1 USD
Soba pain rel xs 500 mg tablet0.07 USD
Soba pain reliever 500 mg tablet0.06 USD
Solution; Oral; Acetaminophen 160 mg / 5 ml
Solution; Oral; Acetaminophen 80 mg / 5 ml
Solution; Oral; Acetaminophen 80 mg / ml
Suppositories; Rectal; Acetaminophen 120 mg
Suppositories; Rectal; Acetaminophen 325 mg
Suppositories; Rectal; Acetaminophen 650 mg
Syrup; Oral; Acetaminophen 160 mg / 5 ml
Tablets, Chewable; Oral; Acetaminophen 160 mg
Tablets, Extended Release; Oral; Acetaminophen 650 mg
Tablets; Oral; Acetaminophen 160 mg
Tablets; Oral; Acetaminophen 325 mg
Tablets; Oral; Acetaminophen 500 mg
Tavist max-str sinus caplet0.17 USD
Tavist nd 10 mg tablet0.74 USD
Tavist-1 1.34 mg tablet0.5 USD
Tencon tablet1.01 USD
Tylenol 100 325 mg tablet Bottle16.98 USD
Tylenol 325 mg tablet0.07 USD
Tylenol 8 hour 650 mg caplet0.1 USD
Tylenol allergy complete caplet0.19 USD
Tylenol allergy complete gelcap0.19 USD
Tylenol allergy m-s caplet0.22 USD
Tylenol allergy m-s night caplet0.2 USD
Tylenol allergy multi-symptom0.16 USD
Tylenol allergy sinus caplet0.17 USD
Tylenol allergy sinus gelcap0.19 USD
Tylenol allergy sinus geltab0.19 USD
Tylenol arthritis caplet sa0.13 USD
Tylenol arthritis geltab0.18 USD
Tylenol chest congestion caplet0.2 USD
Tylenol cold & flu severe liq0.02 USD
Tylenol cold caplet0.17 USD
Tylenol cold gelcap0.23 USD
Tylenol cold head cong caplet0.21 USD
Tylenol cold head congest caplet0.2 USD
Tylenol cold head congestion0.23 USD
Tylenol cold m-s severe day liquid0.02 USD
Tylenol cold multi-symp caplet0.21 USD
Tylenol cold multi-symp gelcap0.23 USD
Tylenol cold multi-symptom caplet0.22 USD
Tylenol cold relief caplet0.15 USD
Tylenol cold relief nightime0.16 USD
Tylenol cold severe congestion0.21 USD
Tylenol cough & sore throat lq0.02 USD
Tylenol day & night value pack0.12 USD
Tylenol es for arthritis pain0.08 USD
Tylenol ex-str 500 mg caplet0.08 USD
Tylenol ex-str 500 mg gelcap0.05 USD
Tylenol ex-str 500 mg geltab0.09 USD
Tylenol ex-str 500 mg tablet0.13 USD
Tylenol flu max-strn gelcap0.24 USD
Tylenol flu nighttime gelcap0.19 USD
Tylenol nighttime liquid0.02 USD
Tylenol p.m. ex-str geltab0.1 USD
Tylenol pm ex-strength caplet0.1 USD
Tylenol pm ex-strength gelcap0.16 USD
Tylenol pm ex-strength geltab0.08 USD
Tylenol pm liquid0.02 USD
Tylenol severe allergy caplet0.17 USD
Tylenol sinus caplet0.21 USD
Tylenol sinus congest-pain caplet0.19 USD
Tylenol sinus congestion&pain0.2 USD
Tylenol sinus gelcap0.19 USD
Tylenol sinus geltab0.19 USD
Tylenol sinus nighttime caplet0.19 USD
Tylenol sore throat liquid0.02 USD
Tylenol with Codeine #3 300-30 mg tablet1.1 USD
Tylenol with Codeine #4 300-60 mg tablet1.65 USD
Ultracet 37.5-325 mg tablet1.95 USD
Ultracet tablet1.79 USD
Women's tylenol 500-25 capsule0.16 USD

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Acetaminophen destination | category:

Destination is defined as the organism to which the drug or medicine is targeted. For most of the drugs what we discuss, human is the drug destination.
Drug category can be defined as major classification of the drug. For example, an antihistaminic or an antipyretic or anti anginal or pain killer, anti-inflammatory or so.


Acetaminophen Anatomical Therapeutic Chemical codes:

A medicine is classified depending on the organ or system it acts [Anatomical], based on what result it gives on what disease, symptom [Therapeutical], based on chemical composition [Chemical]. It is called as ATC code. The code is based on Active ingredients of the medicine. A medicine can have different codes as sometimes it acts on different organs for different indications. Same way, different brands with same active ingredients and same indications can have same ATC code.


Acetaminophen pharmaceutical companies:

Pharmaceutical companies are drug manufacturing companies that help in complete development of the drug from the background research to formation, clinical trials, release of the drug into the market and marketing of the drug.
Researchers are the persons who are responsible for the scientific research and is responsible for all the background clinical trials that resulted in the development of the drug.


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References

  1. Dailymed."FEVERALL INFANTS (ACETAMINOPHEN) SUPPOSITORY [ACTAVIS MID ATLANTIC LLC]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  2. Dailymed."ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
  3. "acetaminophen". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).

Frequently asked Questions

Can i drive or operate heavy machine after consuming Acetaminophen?

Depending on the reaction of the Acetaminophen after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Acetaminophen not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Acetaminophen addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.

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Review

sdrugs.com conducted a study on Acetaminophen, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Acetaminophen consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

Visitor reports

Visitor reported useful

No survey data has been collected yet

Visitor reported side effects

No survey data has been collected yet

Visitor reported price estimates

No survey data has been collected yet

One visitor reported frequency of use

How often in a day do you take the medicine?
Are you taking the Acetaminophen drug as prescribed by the doctor?

Few medications can be taken 4 times in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Acetaminophen is mentioned below.
Visitors%
4 times in a day1
100.0%

Three visitors reported doses

What is the dose of Acetaminophen drug you are taking?
According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 201-500mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
Visitors%
201-500mg2
66.7%
101-200mg1
33.3%

Visitor reported time for results

No survey data has been collected yet

Three visitors reported administration

The drugs are administered in various routes, like oral or injection form. They are administered before food or after food. How are you taking Acetaminophen drug, before food or after food?
Click here to find out how other users of our website are taking it. For any doubts or queries on how and when the medicine is administered, contact your health care provider immediately.
Visitors%
Empty stomach2
66.7%
With a meal1
33.3%

Eight visitors reported age

Visitors%
> 604
50.0%
6-152
25.0%
46-601
12.5%
< 11
12.5%

Visitor reviews


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The information was verified by Dr. Arunabha Ray, MD Pharmacology

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