advertisement
ATC Level5: C09DB06 - Losartan and Amlodipine
ATC Level1:
- C - Cardiovascular system
ATC Level2:
- C09 - Agents acting on the renin
ATC Level3:
- C09D - Angiotensin II antagonists, combinations
ATC Level4:
- C09DB - Angiotensin II antagonists and calcium channel blockers
ATC Level5:
- C09DB06 - Losartan and Amlodipine
Drugs in ATC category "C09DB06":
- Amlodipine
- Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth...
- Asomex-LT
- Esam-LT
- Eslo Tan
- Espin-LT
- Losartan
- Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the...
advertisement
The information was verified by Dr. Rachana Salvi, MD Pharmacology
© 2002 - 2024 "sdrugs.com". All Rights Reserved