Active ingredient: Glyburide

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Glyburide uses

Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide’s hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of Glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m2.

Indication: Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Glyburide, a second-generation sulfonylurea antidiabetic agent, lowers blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonyl-urea hypoglycemic drugs. The combination of glibenclamide and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different but complementary mechanisms. In addition to its blood glucose lowering actions, Glyburide produces a mild diuresis by enhancement of renal free water clearance. Glyburide is twice as potent as the related second-generation agent glipizide.


Glyburide available forms, composition, doses:

Apo-Glyburide 2.5 mg Tablet0.04 USD
Apo-Glyburide 5 mg Tablet0.07 USD
Diabeta 1.25 mg tablet0.5 USD
Diabeta 2.5 mg tablet0.14 USD
Diabeta 5 mg tablet0.26 USD
Euglucon 2.5 mg Tablet0.04 USD
Euglucon 5 mg Tablet0.07 USD
Glynase 1.5 mg prestab0.82 USD
Glynase 1.5 mg tablet0.83 USD
Glynase 3 mg prestab1.39 USD
Glynase 3 mg tablet1.45 USD
Glynase 6 mg prestab2.19 USD
Glynase 6 mg tablet2.28 USD
Micronase 1.25 mg tablet0.48 USD
Micronase 2.5 mg tablet0.8 USD
Micronase 5 mg tablet1.36 USD
Mylan-Glybe 2.5 mg Tablet0.04 USD
Mylan-Glybe 5 mg Tablet0.07 USD
Novo-Glyburide 2.5 mg Tablet0.04 USD
Novo-Glyburide 5 mg Tablet0.07 USD
Nu-Glyburide 2.5 mg Tablet0.04 USD
Nu-Glyburide 5 mg Tablet0.07 USD
Pms-Glyburide 2.5 mg Tablet0.04 USD
Pms-Glyburide 5 mg Tablet0.07 USD
Ratio-Glyburide 2.5 mg Tablet0.04 USD
Ratio-Glyburide 5 mg Tablet0.07 USD
Sandoz Glyburide 5 mg Tablet0.07 USD
Sandoz Glyburide 2.5 mg Tablet0.04 USD
Tablets; Oral; Glyburide 1.25 mg
Tablets; Oral; Glyburide 1.5 mg
Tablets; Oral; Glyburide 2.5 mg
Tablets; Oral; Glyburide 3 mg
Tablets; Oral; Glyburide 4.5 mg
Tablets; Oral; Glyburide 5 mg
Tablets; Oral; Glyburide 6 mg

Indications and Usages:

ATC codes:

ICD-10 codes:

Glyburide destination | category:


Drugs with same active ingredients (Pharmaceutical companies):



Frequently asked Questions

Can i drive or operate heavy machine after consuming Glyburide?

Depending on the reaction of the Glyburide after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Glyburide not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.

Is Glyburide addictive or habit forming?

Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.

Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.


Review conducted a study on Glyburide, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Glyburide consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.

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The information was verified by Dr. Rachana Salvi, MD Pharmacology

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