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DRUGS & SUPPLEMENTS
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Active ingredient: Fluoxetine Hydrochloride
What is the dose of the medication you are taking? |
Fluoxetine Hydrochloride uses
Pharmacological action
Fluoxetine Hydrochloride is an antidepressant, propylamine derivative. The mechanism of action is associated with selective blockade of the inverse of neuronal serotonin reuptake in the CNS. Fluoxetine Hydrochloride is a weak antagonist of choline, adrenergic and histamine receptors. Unlike most antidepressants Fluoxetine Hydrochloride apparently does not cause reduction of functional activity of postsynaptic beta-adrenergic receptors. This medication improves mood, reduces anxiety and stress, eliminates dysphoria. Fluoxetine Hydrochloride does not cause sedation. When you receive a medium therapeutic doses of this drug it does not affect the function of cardiovascular and other systems.
Pharmacokinetics
Fluoxetine Hydrochloride absorbed from the gastrointestinal tract. This medication is poorly metabolized in the "first pass" through the liver. The ingestion did not affect the extent of absorption, although it may slow its speed. Cmax in plasma is reached after 6-8 hours. Css in plasma is reached only after a continuous reception in a few weeks. The protein binding is 94.5%. Fluoxetine Hydrochloride easily penetrates through the BBB.
Fluoxetine Hydrochloride metabolized in the liver by demethylation to form the main active metabolite norfluoxetine.
T1/2 of Fluoxetine Hydrochloride is 2-3 days, norfluoxetine - 7-9 days.
Why is Fluoxetine Hydrochloride prescribed?
Depressions of various origins, obsessive-compulsive disorders, bulimic neurosis.
Dosage and administration
The initial dose of Fluoxetine Hydrochloride is 20 mg 1 time / day in the morning, if necessary, the dose may be increased in 3-4 weeks. The frequency of reception is 2-3 times / day.
The maximum oral daily dose for adults is 80 mg.
Fluoxetine Hydrochloride side effects, adverse reactions
CNS: anxiety, tremors, nervousness, drowsiness, headache, sleep disturbances.
Digestive system: diarrhea, nausea.
Metabolism: increased sweating, hypoglycemia, hyponatremia.
Reproductive system: decreased libido.
Allergic reactions: skin rash, itching.
Other: pain in joints and muscles, shortness of breath, increased body temperature.
Fluoxetine Hydrochloride contraindications
Glaucoma, bladder atony, severe renal dysfunction, benign prostatic hyperplasia, co-administration of MAO inhibitors, convulsions of various origins, epilepsy, pregnancy, lactation, hypersensitivity to Fluoxetine Hydrochloride.
Using during pregnancy and breastfeeding
Fluoxetine Hydrochloride is contraindicated during pregnancy and lactation.
Special instructions
Fluoxetine Hydrochloride should be used with caution in patients with impaired liver and kidney, with a history of epileptic seizures, cardio-vascular diseases.
Patients with diabetes may change in blood glucose levels that require correction dosing regimen of hypoglycemic drugs. When applied in debilitated patients with Fluoxetine Hydrochloride increases the risk of epileptic seizures.
With the simultaneous application of Fluoxetine Hydrochloride and electroconvulsive therapy may develop prolonged seizures.
Fluoxetine Hydrochloride can be applied not earlier than 14 days after discontinuation of MAO inhibitors. The period after the abolition of Fluoxetine Hydrochloride before therapy MAO inhibitors should not be less than 5 weeks.
Elderly patients need correction of dosing regimen.
Safety of Fluoxetine Hydrochloride in children has not been established.
During the period of treatment it needed to avoid use alcohol.
During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.
Fluoxetine Hydrochloride drug interactions
Simultaneous administration of Fluoxetine Hydrochloride with:
Fluoxetine Hydrochloride in case of emergency / overdose
Symptoms: nausea, vomiting, agitation, restlessness, hypomania, seizures, large seizures. There were describes two deaths from acute overdose of Fluoxetine Hydrochloride (in combination with maprotiline, codeine, temazepam).
Treatment: gastric lavage, taking activated charcoal, sorbitol, ECG monitoring, symptomatic and supportive therapy, when convulsions - diazepam. There is no specific antidote. Forced diuresis, peritoneal dialysis, hemodialysis, blood transfusions are ineffective.
Fluoxetine Hydrochloride available forms, composition, doses:
Indications and Usages:
ATC codes:
ICD-10 codes:
Fluoxetine Hydrochloride destination | category:
Drugs with same active ingredients (Pharmaceutical companies):
References
- Dailymed."SARAFEM (FLUOXETINE HYDROCHLORIDE) TABLET [ALLERGAN, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "fluoxetine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "fluoxetine". http://www.drugbank.ca/drugs/DB0047... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Fluoxetine Hydrochloride?Depending on the reaction of the Fluoxetine Hydrochloride after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Fluoxetine Hydrochloride not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Fluoxetine Hydrochloride addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Fluoxetine Hydrochloride, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Fluoxetine Hydrochloride consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetOne visitor reported price estimates
What is your opinion about drug cost? Did you feel the cost is apt, or did you feel it is expensive?The report given by the sdrugs.com website users shows the following figures about several people who felt the medicine Fluoxetine Hydrochloride is expensive, and the medicine is not expensive. The results are mixed. The perception of the cost of the medicine to be expensive or not depends on the brand name of the medicine, country, and place where it is sold, and the affordability of the patient. You can choose a generic drug in the place of the branded drug to save the cost. The efficiency of the medicine will not vary if it is generic or a branded one.
| Visitors | % | ||
|---|---|---|---|
| Expensive | 1 | 100.0% | |
One visitor reported frequency of use
How often in a day do you take the medicine?Are you taking the Fluoxetine Hydrochloride drug as prescribed by the doctor?
Few medications can be taken Once in a day more than prescribed when the doctor's advice mentions the medicine can be taken according to frequency or severity of symptoms. Most times, be very careful and clear about the number of times you are taking the medication. The report of sdrugs.com website users about the frequency of taking the drug Fluoxetine Hydrochloride is mentioned below.
| Visitors | % | ||
|---|---|---|---|
| Once in a day | 1 | 100.0% | |
One visitor reported doses
What is the dose of Fluoxetine Hydrochloride drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 11-50mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 11-50mg | 1 | 100.0% | |
Visitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology