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DRUGS & SUPPLEMENTS
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Heximet
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Heximet uses
Heximet consists of Chlorhexidine Gluconate, Metronidazole Benzoate.Chlorhexidine Gluconate:
Pharmacological action
Heximet is an antiseptic agent. Heximet (Chlorhexidine Gluconate) is active against vegetative forms of gram-negative and gram-positive bacteria and yeasts, dermatophytes and lipophilic viruses. This medicine has effect for bacterial spores only at elevated temperatures. It cleans and disinfects the skin without causing damage.
Why is Heximet (Chlorhexidine Gluconate) prescribed?
For local use of Heximet (Chlorhexidine Gluconate) Pharmaniaga: trichomonas coleitis, cervical erosion, itching of the vulva, prevention of sexually transmitted diseases (including gonorrhea, syphilis, trichomoniasis, chlamydia, ureaplasmosis); gingivitis, stomatitis, aphthae, paradont, alveolitis, disinfection of removable dentures, sore throat; postoperative care for patients in ENT and dentistry.
Treatment of wounds, burn wounds and surfaces, disinfection of the patient's skin.
Treatment of surgeons', nurses' hands and operating field before diagnostic manipulation operation.
Disinfection of work surfaces of devices (including thermometers) and equipment which heat treatment is not desirable.
Dosage and administration
The dose and method of Heximet application depend on the testimony and dosage form of Heximet (Chlorhexidine Gluconate).
Use only locally. 0,5% alcohol or 1% aqueous solution for 2-5 min is applied to the corresponding surface. In dentistry solution for mouthwash and gel are prescribed 2-3 times a day.
Heximet (Chlorhexidine Gluconate) side effects, adverse reactions
Perhaps allergic reaction. Dry and itchy skin, dermatitis, stickiness of hands for 3-5 min, stained teeth, the deposition of tartar, breach of taste (in the treatment of gingivitis).
Heximet contraindications
Hypersensitivity to Heximet (Chlorhexidine Gluconate), dermatitis, allergic reactions.
Special instructions
Remains active in the presence of impurities of blood and organic matter. Should not enter the Heximet in the eye (except for special dosage form prescribed for washing the eye), as well as contact with the meninges and the auditory nerve.
Avoid using Heximet (Chlorhexidine Gluconate) with iodine preparations.
Heximet (Chlorhexidine Gluconate) drug interactions
Heximet (Chlorhexidine Gluconate) is incompatible with the soap, and detergents containing anionic group (saponins, sodium lauryl sulfate, sodium carboxymethyl cellulose).
Heximet (Chlorhexidine Gluconate) is compatible with any medication containing cationic group (cetrimonium bromide, benzalkonium chloride).
Metronidazole Benzoate:
Pharmacological action
Heximet is an anti protozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, and obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.).
Aerobic bacteria are resistant to Heximet (Metronidazole Benzoate).
In combination with amoxicillin Heximet (Metronidazole Benzoate) is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of resistance of Helicobacter pylori to Heximet (Metronidazole Benzoate).
Pharmacokinetics
Heximet (Metronidazole Benzoate) well absorbed after oral administration. The bioavailability is 80%. Heximet (Metronidazole Benzoate) is distributed in tissues and body fluids. This medication crosses the placental barrier and the BBB. Binding to plasma proteins is 20%. Heximet (Metronidazole Benzoate) is metabolized in the liver by oxidation and binding to glucuronic acid. T1/2 is 8 hours. This drug is excreted in the urine (60-80%) and feces (6-15%).
Why is Heximet prescribed?
Trichomonazice vaginitis and urethritis in women, trichomonazice urethritis in men, giardiasis, amoebic dysentery, anaerobic infections caused by metronidazole-sensitive organisms, combination therapy of severe mixed aerobic-anaerobic infections. Preventing anaerobic infection in surgery (particularly abdominal, urinary tract). Chronic alcoholism.
Heximet (Metronidazole Benzoate) in combination with amoxicillin: chronic gastritis in acute phase, gastric ulcer and duodenal ulcer in acute phase, associated with Helicobacter pylori.
For external and topical use: treatment of acne vulgaris and pink, bacterial vaginosis, treatment of long-term healing of wounds and trophic ulcers.
Dosage and administration
Heximet is administered for oral use for adults and children over 12 years in 7.5 mg / kg every 6 h or 250-750 mg 3-4 times / day. For children up to 12 years the dose is 5-16.7 mg / kg 3 times / day. For IV injections for adults and children over 12 years starting dose is 15 mg / kg, followed by 7.5 mg / kg every 6 hours or depending on the etiology of the disease - by 500-750 mg every 8 hours. The duration of treatment and frequency of tests is determined individually.
Intravaginally - 500 mg 1 time a night.
In combination with amoxicillin (2.25 g / day) daily dose of Heximet (Metronidazole Benzoate) is 1.5 g; multiplicity of admission - 3 times / day. For patients with severe renal impairment (creatinine clearance less than 30 ml / min) and / or liver daily dose of Heximet (Metronidazole Benzoate) is 1 g (amoxicillin - 1.5 g / day), the multiplicity of the reception is 2 times / day. This medication takes for external and local use 2 times / day, doses are determined individually.
The maximum daily dose for adults when taken orally and IV is 4 g.
Heximet (Metronidazole Benzoate) side effects, adverse reactions
Digestive system: nausea, vomiting, anorexia, metallic taste in the mouth.
CNS and peripheral nervous system: headache, nervousness, irritability, insomnia, dizziness, ataxia, weakness, confusion, depression, peripheral neuropathy, seizures, hallucinations.
Allergic reactions: skin rash, itching, hives.
Hemopoietic system: leucopenia.
Local reactions: irritation.
Other: arthralgia, burning sensation in the urethra.
Heximet contraindications
Organic CNS lesions, blood diseases, liver problems, I trimester of pregnancy, hypersensitivity to Heximet (Metronidazole Benzoate).
Using during pregnancy and breastfeeding
Heximet is rapidly crosses the placental barrier. In II and III trimester of pregnancy Heximet (Metronidazole Benzoate) is used only for health reasons.
Heximet (Metronidazole Benzoate) is excreted in breast milk. If necessary, use during lactation should solve the issue of termination of breastfeeding.
Special instructions
Patients should with careful use of Heximet (Metronidazole Benzoate) in liver diseases.
In combination with amoxicillin this medication is not recommended for patients younger than 18 years. During the treatment period it is necessary the regular control of pattern of peripheral blood.
During the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men patients should refrain from sexual activity, simultaneous treatment of both partners is mandatory.
During the taking of Heximet (Metronidazole Benzoate) there is a more dark staining of urine.
During treatment with Heximet (Metronidazole Benzoate) should avoid alcohol because to violations of the oxidation of alcohol can accumulate acetaldehyde. As a result may develop reactions similar to those characteristic of disulfiram (abdominal cramps, nausea, vomiting, headache, a sudden rush of blood to the face).
Heximet drug interactions
Simultaneous administration of Heximet (Metronidazole Benzoate) with:
Heximet in case of emergency / overdose
Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and seizures.
Treatment: symptomatic, there is no specific antidote.
Heximet pharmaceutical active ingredients containing related brand and generic drugs:
Heximet available forms, composition, doses:
Heximet destination | category:
Heximet Anatomical Therapeutic Chemical codes:
Heximet pharmaceutical companies:
References
- Dailymed."MAX CHLORHEXIDINE (CHLORHEXIDINE GLUCONATE) SHAMPOO [ANIMAL PHARMACEUTICALS]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- Dailymed."CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Heximet?Depending on the reaction of the Heximet after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Heximet not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Heximet addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Heximet, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Heximet consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
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The information was verified by Dr. Rachana Salvi, MD Pharmacology