Synovex Choice

Estradiol Benzoate:

• Synovex Choice information
• Synovex Choice indications
• Synovex Choice warnings
• Synovex Choice intake guidelines
• Synovex Choice dosage
• Synovex Choice overdose
• Synovex Choice missed dose
• Synovex Choice side effects
• Synovex Choice drug reactions
• Synovex Choice (Estradiol Benzoate) reviews

Synovex Choice information

Synovex Choice (Estradiol Benzoate) is a female sex hormone that regulates many functions in the female organism. This medicine is currently available under the form of tablets in two concentrations - 1 mg and 2 mg, respectively.

Synovex Choice indications

Synovex Choice (Estradiol Benzoate) is used for the treatment of menopausal symptoms such as vaginal dryness, irritation or burning, or hot flushes - other symptoms that are not listed here may be treated with this medicine as well. Also, this pharmaceutical preparation can be used as a prophylactic agent for the prevention of a medical condition known as osteoporosis in both female and male patients. In some cases, this medicine may also be employed in conjunction with other drugs as part of the treatment for certain types of cancer, both in the case of women and men.

There may be other uses for Synovex Choice (Estradiol Benzoate), which are not covered in this leaflet. If you are interested to find out more about the possible uses of this product, it is recommended that you consult with a pharmacist or a specialized physician.

Synovex Choice warnings

Synovex Choice (Estradiol Benzoate) should not be administered to patients that are suffering from any type of disorder involving blood clots, or from circulatory / cardiac disorders. Patients who present an undiagnosed, abnormal vaginal bleeding may not start taking this medicine until they undergo medical examination and receive their physician's approval. Also, patients that have uterine cancer, breast cancer or any type of hormone-dependant cancer may not start a treatment with Synovex Choice (Estradiol Benzoate).

Before you start a therapy course with this drug, it is strongly advised to inform your personal physician of any health problems you may be suffering from. In particular, affections such as hypertension, heart disease, angina, high triglyceride / cholesterol levels, renal or hepatic disease, asthma, migraines, epilepsy (or any other disorder involving seizures), diabetes or gallbladder disease should be mentioned, as well as past surgical procedures such as a hysterectomy. Patients suffering from these conditions may require special dosage adjustments or monitoring during the treatment.

Synovex Choice (Estradiol Benzoate) may not be administered during pregnancy. Also, for the duration of the therapy you will need to employ an effective, non-hormonal contraceptive method.

Pharmaceutical products based on Estradiol (including Synovex Choice (Estradiol Benzoate)) increase the patients' risk of developing an affection known as endometrial hyperplasia. This can be countered by administration of progestin medication. It is recommended that you consult with your doctor for more information.

Synovex Choice intake guidelines

You need to take Synovex Choice (Estradiol Benzoate) exactly as directed by your health care specialist. You may take the tablets with a glass of water or with food to reduce stomach upset; however you may not chew, crush or break the tablets.

While following a treatment course with Synovex Choice (Estradiol Benzoate) you will need to undergo regular medical examination, typically on a monthly basis. Also, you will need to regularly self-examine your breasts for the presence of lumps.

Synovex Choice dosage

Your health care specialist will determine the Synovex Choice (Estradiol Benzoate) dosage appropriate for your case by taking into consideration a number of factors, most of which are characteristic to you; as such, your medication dosage is very likely to be different from that of other patients'. Because of that, you should never use the Synovex Choice (Estradiol Benzoate) dosage that has been prescribed to another patient - you may not obtain the desired results unless you employ the medication dosage best suited for your situation.

At the same time, your physician will inform you regarding the duration of the Synovex Choice (Estradiol Benzoate) therapy and the number of daily intakes. Make sure that you understand all of his or her indications. If you have trouble understanding or remembering any of the dosage directions, you should ask your physician to assist you by providing additional information.

Synovex Choice overdose

If an overdose with Synovex Choice (Estradiol Benzoate) is suspected, immediately contact the nearest hospital as the patient may need emergency medical assistance. The most common signs of an overdose are vaginal bleeding, nausea and vomiting.

Synovex Choice missed dose

In the event that you miss taking one of your Synovex Choice (Estradiol Benzoate) doses, take it when you remember before returning to your normal dosing schedule. However, you should skip taking the missed dose if it is almost time for another dose of the medicine. Consult with your physician if you have missed two or more intakes.

Synovex Choice side effects

Side effects of a treatment with Synovex Choice (Estradiol Benzoate) include nausea and vomiting, loss of appetite, swelling of the breasts, sex drive changes, impotence (in the case of men), abnormal vaginal bleeding, vaginal dryness, discomfort or pain, break-through bleeding, menstrual period changes, jaundice, sudden weakness or numbness, breast lumps. These are not all the signs and symptoms that may appear. It is best that you check with your doctor at any point during the course of your therapy if anything unusual occurs.

Although uncommon, allergic reactions to Synovex Choice (Estradiol Benzoate) are possible. It is strongly recommended that you cease taking the medicine and contact your personal health care provider if you begin experiencing any of the characteristic symptoms - breathing difficulties, swelling of the throat, lips, tongue or face, rashes and hives.

Synovex Choice drug reactions

Synovex Choice (Estradiol Benzoate) may interact with Phenobarbital, Phenytoin, Ritonavir, Cimetidine, Carbamazepine, Rifampin, blood thinning agents such as Warfarin or with antibiotics (Clarithromycin, Erythromycin, Ketoconazole or Itraconazole). Also, this product may interact with the herbal remedy St. John's wort. These are not all the possible drug reactions; it is best that you tell your prescriber about any other drugs you are currently taking prior to starting your treatment. In most cases, an adjustment to the medication dosage will ensure the safety of the treatment, reducing the risk of accidental interactions.

Trenbolone Acetate:

• Synovex Choice (Trenbolone Acetate) reviews

GRASS

(trenbolone and estradiol extended release implant)

150 mg Synovex Choice (Trenbolone Acetate) acetate and 21 mg estradiol benzoate per implant

SUBCUTANEOUS IMPLANTS FOR PASTURE STEERS AND HEIFERS (SLAUGHTER, STOCKER AND FEEDER)

NADA 141-348, Approved by FDA

Synovex Choice (Trenbolone Acetate) Grass (trenbolone and estradiol extended release implant) is a growth promoting implant containing 150 mg of Synovex Choice (Trenbolone Acetate) acetate and 21 mg of estradiol benzoate with a porous polymer film coating that extends the pay-out period of the final formulation up to 200 days. Each implant consists of 6 pellets. Ten implants are provided in each cartridge.

INDICATIONS FOR USE: For increased rate of weight gain for up to 200 days in pasture steers and heifers (slaughter, stocker and feeder).

Do not use in veal calves. Effectiveness and animal safety in veal calves have not been established.

Not for use in dairy or beef replacement heifers.

DOSAGE: One implant (6 pellets), containing 150 mg Synovex Choice (Trenbolone Acetate) acetate and 21 mg of estradiol benzoate, is administered to each steer or heifer by subcutaneous implantation in the middle one-third of the ear.

The ten-dose cartridge of Synovex Choice (Trenbolone Acetate) Grass is designed to be used exclusively with a Synovex SX10 Gun.

WITHDRAWAL PERIOD: No withdrawal period is required when used according to labeling.

A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Implant pellets in ear only. Any other location is a violation of Federal law. Do not attempt salvage of implanted site for human or animal food.

NOT FOR USE IN HUMANS.

FOR ANIMAL USE ONLY.

ANIMAL SAFETY WARNING: Bulling, vaginal and rectal prolapse, udder development, ventral edema and elevated tailheads have occasionally been reported in heifers administered Synovex Choice (Trenbolone Acetate) Grass implants.

DIRECTIONS: Implant complete contents of one cartridge cell per steer or heifer. Approved implantation technique is fully described in the fold-out carton section.

NOTE: Never sacrifice careful, clean technique for speed of implantation.

STORAGE: Store unopened product at controlled room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F). Avoid excessive heat and humidity. Use product before the expiration date on the label.

Once the pouch is opened, unused product may be stored in the end-folded pouch (away from light) for up to six months under refrigerated conditions 2°-8°C (36°-47°F) or at room temperature 20°-25°C (68°-77°F) with excursions between 15°-30°C (59°-86°F) for up to one month.

DISPOSAL: Synovex Choice (Trenbolone Acetate) Grass waste materials should be disposed of according to prescribed Federal, State, and Local guidelines.

Manufactured By A Non-Sterilizing Process

Keep this and all drugs out of the reach of children.

Restricted Drug (California)-Use Only As Directed.

Distributed by:

Zoetis Inc.

Kalamazoo, MI 49007

6202A

13798001

NET CONTENTS: 10 Cartridges

Each Cartridge Contains 10 implants (100 implants total)