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DRUGS & SUPPLEMENTS
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Amantadin
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Amantadin uses
Pharmacological action
Amantadin is an antiparkinsonian and antiviral drug, a tricyclic symmetric adamantanamin.
This medication blocks glutamate NMDA-receptors, thus reducing the excessive stimulatory effect of cortical glutamate neurons in the neostriatum that develops against the backdrop of lack of dopamine. Amantadin inhibits NMDA-receptors in the neurons of the substantia nigra reduces the intake of these Ca2+, which reduces the possibility of destruction of these neurons. In a greater Amantadin influences on stiffness.
This medicine inhibits the penetration of influenza A virus into the cell.
Pharmacokinetics
Amantadin after oral administration is completely absorbed from the gastrointestinal tract. Cmax plasma levels achieved after 5 hours. This medication excreted in urine. T1/2 of Amantadin sulfate is 12-13 hours, in contrast to Amantadin hydrochloride, which T1/2 is 30 hours.
Why is Amantadin prescribed?
Parkinson's disease, Parkinson's syndrome.
Neuralgia in Herpes Zoster, caused by the virus Varicella Zoster.
Prevention (including in combination with vaccination) and treatment of influenza A.
Dosage and administration
For oral administration the single dose is 100-200 mg.
IV in the form of infusion in 200 mg during 3 hours.
The frequency and duration of Amantadin use depends on the evidence, the patient's response to treatment, the epidemiological situation.
The maximum dose for oral administration is 600 mg / day.
Amantadin side effects, adverse reactions
CNS: headaches, depression, visual hallucinations, motor or mental excitement, convulsions, irritability, dizziness, sleep disturbances, tremors, mental disorders are accompanied by visual hallucinations, reduced visual acuity.
Cardiovascular system: the development or exacerbation of heart failure, orthostatic hypotension; rarely - arrhythmia, tachycardia.
Digestive system: rarely - anorexia, nausea, constipation, dry mouth.
Urinary system: patients with benign prostatic hyperplasia - difficulty urinating; polyuria, nocturia.
Dermatological reactions: dermatitis, the appearance of a bluish color of the skin of the upper and lower extremities.
Amantadin contraindications
Hepatic failure, chronic renal failure, psychosis (including history), hyperthyroidism, epilepsy, angle-closure glaucoma, prostatic hyperplasia, hypotension, congestive heart failure stage II-III, excited, preddeliry, delirious psychosis, I trimester of pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, increased sensitivity to Amantadin.
Using during pregnancy and breastfeeding
The use of Amantadin in pregnancy is possible only under strict indications and under the supervision of a physician.
If necessary to use during lactation it been should decide on the termination of breastfeeding.
Category of the fetus by FDA - C.
Special instructions
Use Amantadin with caution in patients with impaired renal function, while taking other antiparkinsonian drugs, as well as in the elderly. In such cases a correction of the dosage of Amantadin is needed. Patients with hyperreflexia the cancellation of treatment should be gradual.
An information about the effectiveness of Amantadin to reduce extrapyramidal disorders during treatment with antipsychotic drugs are contradictory.
During treatment avoid drinking alcohol.
In the period of treatment you should not engage in activities that require high concentration and rapid psychomotor reactions.
Amantadin drug interactions
When this drug applied simultaneously with:
- may increase the side effects of other antiparkinsonian medications.
- thiazide diuretics can not been excluded the possibility of toxic effects of Amantadin (ataxia, agitation, hallucinations), probably by reducing its renal clearance.
- quinine, quinidine may decrease the excretion of Amantadin in urine.
There was described a case of acute confusion in elderly patients while this medication was simultaneously used with co-trimoxazole.
Amantadin pharmaceutical active ingredients containing related brand and generic drugs:
Amantadin available forms, composition, doses:
Amantadin destination | category:
Amantadin Anatomical Therapeutic Chemical codes:
Amantadin pharmaceutical companies:
References
- Dailymed."AMANTADINE HYDROCHLORIDE TABLET [ACTAVIS PHARMA, INC.]". https://dailymed.nlm.nih.gov/dailym... (accessed August 28, 2018).
- "amantadine". https://pubchem.ncbi.nlm.nih.gov/co... (accessed August 28, 2018).
- "amantadine". http://www.drugbank.ca/drugs/DB0091... (accessed August 28, 2018).
Frequently asked Questions
Can i drive or operate heavy machine after consuming Amantadin?Depending on the reaction of the Amantadin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Amantadin not safe to drive or operate heavy machine after consumption. Meaning that, do not drive or operate heavy duty machines after taking the capsule if the capsule has a strange reaction on your body like dizziness, drowsiness. As prescribed by a pharmacist, it is dangerous to take alcohol while taking medicines as it exposed patients to drowsiness and health risk. Please take note of such effect most especially when taking Primosa capsule. It's advisable to consult your doctor on time for a proper recommendation and medical consultations.
Is Amantadin addictive or habit forming?Medicines are not designed with the mind of creating an addiction or abuse on the health of the users. Addictive Medicine is categorically called Controlled substances by the government. For instance, Schedule H or X in India and schedule II-V in the US are controlled substances.
Please consult the medicine instruction manual on how to use and ensure it is not a controlled substance.In conclusion, self medication is a killer to your health. Consult your doctor for a proper prescription, recommendation, and guidiance.
Review
sdrugs.com conducted a study on Amantadin, and the result of the survey is set out below. It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Amantadin consumers. We, as a result of this, advice that you do not base your therapeutic or medical decisions on this result, but rather consult your certified medical experts for their recommendations.Visitor reports
Visitor reported useful
No survey data has been collected yetVisitor reported side effects
No survey data has been collected yetVisitor reported price estimates
No survey data has been collected yetVisitor reported frequency of use
No survey data has been collected yetOne visitor reported doses
What is the dose of Amantadin drug you are taking?According to the survey conducted among sdrugs.com website users, the maximum number of people are using the following dose 51-100mg. Few medications come in only one or two doses. Few are specific for adult dose and child dose. The dose of the medicine given to the patient depends on the severity of the symptom/disease. There can be dose adjustments made by the doctor, based on the progression of the disease. Follow-up is important.
| Visitors | % | ||
|---|---|---|---|
| 51-100mg | 1 | 100.0% | |
Visitor reported time for results
No survey data has been collected yetVisitor reported administration
No survey data has been collected yetVisitor reported age
No survey data has been collected yetVisitor reviews
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The information was verified by Dr. Rachana Salvi, MD Pharmacology